Mesh : Child Child, Preschool Chorionic Gonadotropin / therapeutic use Cryptorchidism / classification diagnosis therapy Drug Therapy, Combination Gonadotropin-Releasing Hormone / therapeutic use Guideline Adherence Humans Infant Infant, Newborn Male Orchiopexy Testicular Neoplasms / prevention & control

来  源:   DOI:10.1055/s-0033-1358664

Abstract:
Cryptorchidism, or undescended testis (UDT), occurs in 1-3% of male term infant births. At least two-thirds of UDTs will descend spontaneously, typically during the first 6 months of life. UDTs are associated with loss of spermatogenic potential and testicular malignancy in the long term. Orchiopexy performed prior to puberty may significantly reduce the malignant potential by up to 4-fold. Neoadjuvant hormonal therapy starting at 6 months of life has been shown to potentially improve the testicle\'s fertility index and should be part of the therapeutic concept. However, the use of hormonal treatment and HCG beyond the first year of life is to be challenged given a potentially negative impact on testicular function. Laparoscopic exploration and therapy is the method of choice for non-palpable testes. Ideally, surgical repair of the UDT should be completed by the age of 1 year.
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