Mesh : Amino Acid Sequence Animals Annexin A5 Annexins Antibodies, Monoclonal / immunology Calcium-Binding Proteins / metabolism Calmodulin-Binding Proteins / metabolism Endoplasmic Reticulum / metabolism Epitopes Intracellular Membranes / metabolism Oncogene Protein pp60(v-src) Peptide Fragments / analysis Proto-Oncogene Proteins / metabolism Proto-Oncogene Proteins pp60(c-src) Retroviridae Proteins / metabolism

来  源:   DOI:10.1038/320636a0

Abstract:
A group of calcium-binding proteins which bind to biomembranes has recently been identified in widely different cells and tissues (refs 1-7, reviewed in ref. 8). Three of these proteins (p70, p36 and p32.5) cross-react with antiserum to calelectrin, a Ca2+-binding protein (relative molecular mass 34,000 (34K] from the ray Torpedo marmorata, giving rise to their designation as calelectrin-related proteins. We now report that calelectrin, p36 and p32.5 contain a 17-amino-acid consensus sequence which is conserved and present in multiple copies. We suggest that this sequence may be common to other members of this new group of Ca2+-binding proteins and may underlie their unusual mode of combination with biomembranes.
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