PDF(Sci-hub)
Abstract：
Scorpion venoms are rich sources of biologically active peptides that are classified into disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are the main scorpion venom components responsible for the neurotoxic effects observed during scorpion envenomation as they usually target membrane bound ion channels of excitable and non-excitable cells. Several hundred DBPs have been identified and functionally characterized in the past two decades. The NDBPs represent a novel group of molecules that have gained great interest only recently due to their high diversity both in their primary structures and bioactivities. This review provides an overview of scorpion NDBPs focusing on their therapeutic applications, modes of discovery, mechanisms of NDBPs genetic diversity and structural properties. It also provides a simple classification for NDBPs that could be adopted and applied to other NDBPs identified in future studies.
摘要：
蝎毒是生物活性肽的丰富来源，分为二硫键桥肽（DBPs）和非二硫键桥肽（NDBPs）。DBPs是负责蝎毒过程中观察到的神经毒性作用的主要蝎毒成分，因为它们通常靶向可兴奋和不可兴奋细胞的膜结合离子通道。在过去的二十年中，已经确定了数百个DBP并对其进行了功能表征。NDBPs代表了一组新的分子，由于其一级结构和生物活性的高度多样性，它们最近才获得了极大的兴趣。这篇综述概述了蝎子NDBPs的治疗应用，发现模式，NDBPs遗传多样性和结构特性的机制。它还为NDBPs提供了一个简单的分类，可以采用并应用于未来研究中确定的其他NDBPs。
