关键词: ABC AE Adverse events Bevacizumab Breast cancer CT EGFR Everolimus FDA Food and Drug Administration HER2 LVEF Lapatinib Pertuzumab QoL RCC T-DM1 Trastuzumab Trastuzumab emtansine Trastuzumab-emtansine VEGF advanced breast cancer adverse event computed tomography epidermal growth factor receptor human epidermal growth factor receptor type 2 left ventricular ejection fraction mTOR quality of life renal cell cancer the mammalian target of rapamycin vascular endothelial growth factor

Mesh : Ado-Trastuzumab Emtansine Angiogenesis Inhibitors / adverse effects Antibodies, Monoclonal, Humanized / adverse effects Antineoplastic Agents / adverse effects Bevacizumab Biological Therapy / adverse effects Breast Neoplasms / drug therapy Drug-Related Side Effects and Adverse Reactions / prevention & control Everolimus Humans Immunosuppressive Agents / adverse effects Lapatinib Maytansine / adverse effects analogs & derivatives Quinazolines / adverse effects Sirolimus / adverse effects analogs & derivatives Trastuzumab

来  源:   DOI:10.1016/j.breast.2013.09.009

Abstract:
In recent years, a number of new molecules - commonly known as biological therapies - have been approved or are in late stages of regulatory evaluation for the treatment of advanced breast cancer. These innovative compounds have improved treatment efficacy and have probably contributed to the increase in survival length observed in some breast cancer subtypes. However, these agents are not deprived of toxicity, which can impair quality of life and may occasionally be life-threatening. In this article, we reviewed the most common toxicities associated with these drugs and provided a number of practical recommendations on their optimal clinical management.
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