关键词: 47 XXX congenital hypothyroidism craniofacial features dental changes triple X syndrome

Mesh : Child Chromosomes, Human, X Congenital Hypothyroidism / complications physiopathology Face Female Humans Sex Chromosome Aberrations Sex Chromosome Disorders of Sex Development / complications physiopathology Tooth Eruption Trisomy / physiopathology

来  源:   DOI:10.1111/scd.12050   PDF(Sci-hub)

Abstract:
Triple X syndrome (47,XXX) is a numerical chromosomal alteration that affects 1/1,000 women, in which the woman is born with an extra X chromosome. Some oral changes have been reported in the literature, as hypodontia, influence on deposition of crown enamel and discrepancies in cephalometric measurements. Other systemic complications may lead to oral abnormalities similar to those seen in triple X patients, such as congenital hypothyroidism (CH). This paper reports a triple X syndrome case associated with CH later treated. Besides delay in cognitive and intellectual development, the patient had changes in teeth development and in cephalometric measurements with deficiencies in the maxilla and mandible. This is the first report of a triple X syndrome associated with CH. Both conditions may result in changes in dentofacial development.
摘要:
三X综合征(47,XXX)是一种影响1/1,000女性的数字染色体改变,女性出生时带有额外的X染色体。文献中已经报道了一些口头变化,作为低度,对牙釉质沉积的影响和头颅测量的差异。其他全身性并发症可能导致类似于三X患者的口腔异常,如先天性甲状腺功能减退症(CH)。本文报道了与后来治疗的CH相关的三重X综合征病例。除了认知和智力发展的延迟,患者的牙齿发育和头颅测量发生变化,上颌骨和下颌骨不足。这是与CH相关的三重X综合征的首次报道。这两种情况都可能导致牙面发育的变化。
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