脆性 X 蛋白结合参与癌症进展的 mRNA 并调节转移形成。
关键词: EMT FMRP TNBC cell invasion mRNA metabolism
Mesh : Animals Breast Neoplasms / metabolism pathology Cadherins / metabolism Cell Adhesion Cell Line, Tumor Cell Movement Cell Shape Disease Progression Epithelial-Mesenchymal Transition Female Fragile X Mental Retardation Protein / antagonists & inhibitors genetics metabolism Humans Immunohistochemistry Lung Neoplasms / metabolism pathology secondary Mice RNA Interference RNA, Messenger / metabolism RNA, Small Interfering / metabolism Vimentin / metabolism
来 源:
DOI:10.1002/emmm.201302847
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