17 β - 雌二醇对心肌细胞缺氧 / 复氧的心脏保护作用部分是通过上调 CRH 受体 2 型。
关键词: 17β-estradiol CRHR2 Cardiomyocytes Corticotropin-releasing hormone receptor type 2 E2 ER EREs Estrogens H/R Hypoxia/reoxygenation IHD IPC LDH Lactate Dehydrogenase MTT RIA Radioimmunoassay Sp1 Specific protein1 UCN Urocortins corticotrophin-releasing hormone receptor type 2 estrogen receptor estrogen responses elements hypoxia/reoxygenation ischemic heart disease ischemic preconditioning methyl thiazolyl tetrazolium siRNA small interfering RNA specific protein 1 urocortin
Mesh : Animals Cardiotonic Agents / pharmacology Cell Hypoxia / drug effects Down-Regulation / drug effects Estradiol / pharmacology Estrogen Receptor alpha / agonists metabolism Female Gene Knockdown Techniques Mice Myocardium / metabolism Myocytes, Cardiac / drug effects metabolism Ovariectomy Oxygen / pharmacology Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors metabolism Sp1 Transcription Factor / metabolism Up-Regulation / drug effects Urocortins / pharmacology
来 源:
DOI:10.1016/j.mce.2013.09.002
PDF(Sci-hub)