葡萄糖的可用性是 Nrf2 介导的基因表达的决定性因素。
关键词: 3BP, 3-bromopyruvate ATP, adenosine triphosphate DCF, dichloroflourescein DHEA, dehydroandrostendione DMSO, dimethylsulfoxide G6PD, glucose 6-phosphate dehydrogenase GR, glutathione reductase Glucose addiction Glut1, glucose transporter 1 HO-1, heme oxygenase-1 Keap1, Kelch-like ECH-associated protein1 MEF, mouse embryonic fibroblasts Maf, small masculoaponeurotic fibrosarcoma NADP, nicotine adenine dinucleotide phosphate NQO1, NAD(P)H:quinone oxidoreductase 1 Nrf2 Nrf2, nuclear factor-erythroid 2-related factor 2 OXPHOS, oxidative phosphorylation PBS, phosphate buffered saline PPP, pentose phosphate pathway ROS detoxification ROS, reactive oxygen species SFN, sulforaphane WT, wild type ctrl, control
Mesh : Adaptor Proteins, Signal Transducing / genetics metabolism Animals Cells, Cultured Cytoskeletal Proteins / genetics metabolism Fibroblasts / metabolism Gene Knockdown Techniques Glucose / metabolism Isothiocyanates / pharmacology Kelch-Like ECH-Associated Protein 1 Mice NADP / metabolism NF-E2-Related Factor 2 / genetics metabolism Oxidative Stress Pentose Phosphate Pathway Sulfoxides
来 源:
DOI:10.1016/j.redox.2013.06.001
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