关键词: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 3-[4,5-dimethylthiazol-2–yl]-2,5-diphenyltetrazolium bromide APL Apoptosis Arsenic trioxide As(2)O(3) B-cell CLL/lymphoma2 BCL2-associated X protein Bax Bcl2 CatL Cathepsin L ECM GBM Glioblastoma multiforme MTS MTT Multicellular resistance effect STS TNFα U87MG cells transduced with lentiviruses encoding scrambled shRNA expression vector U87MG cells transduced with lentiviruses encoding shRNA expression vector for stable silencing of Cathepsin L U87MG spheroids U87MG-sc U87MG-si acute promyelocytic leukaemia arsenic trioxide extracellular matrix glioblastoma multiforme p53 shRNA short hairpin RNA siRNA small interfering RNA staurosporine tumour necrosis factor alpha tumour protein 53
Mesh : Apoptosis Arsenic Trioxide Arsenicals Brain Neoplasms / metabolism pathology Cathepsin L / antagonists & inhibitors genetics metabolism Cell Line, Tumor Cell Survival Gene Silencing Glioblastoma / metabolism pathology Humans Oxides / toxicity Spheroids, Cellular / drug effects metabolism Tumor Cells, Cultured
来 源: DOI:10.1016/j.yexcr.2013.08.011