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Abstract：
OBJECTIVE: Low birth weight (LBW; below 2500 grams) is a general risk factor for a variety of neurodevelopmental difficulties. However, these children may remain more vulnerable to neurologic and environmental insults occurring years later. This prospective case series reports on children who sustained a mild, moderate, or severe traumatic brain injury (TBI) in middle childhood but who had also been born with birth weights below 2500 grams.
METHODS: PARTICIPANTS were 14 children with mild, moderate, or severe traumatic brain injury (TBI), 5 of whom had birth weights under 2500 grams (LBW) and 9 children with normal birth weight (NBW). All participants were drawn from a larger study on the long-term cognitive and behavioral impact of pediatric TBI and were matched on age, estimated socioeconomic status (SES), and severity of TBI (with NBW children actually having a slightly worse overall injury severity).
RESULTS: At baseline, both groups exhibited similar scores on WJ-R Letter Word Identification and Calculations, Tower of London number solved, and CVLT-C total correct. Baseline group differences were observed on the CELF-III Formulated Sentences (NBW > LBW) and on the VABS Adaptive Behavior Composite and Socialization subdomain (LBW > NBW). Over 2 years, relative to the NBW group, the LBW group evidenced declines on both WJ-R subtests, CVLT-C total correct, CELF-III Formulated Sentences, and VABS Adaptive Behavior Composite and Socialization.
CONCLUSIONS: Although preliminary in nature due to small sample size, findings suggest a history of LBW influences the recovery trajectory following childhood TBI. Academic and adaptive functioning and verbal memory appeared particularly affected.
METHODS: PARTICIPANTS were 14 children with mild, moderate, or severe traumatic brain injury (TBI), 5 of whom had birth weights under 2500 grams (LBW) and 9 children with normal birth weight (NBW). All participants were drawn from a larger study on the long-term cognitive and behavioral impact of pediatric TBI and were matched on age, estimated socioeconomic status (SES), and severity of TBI (with NBW children actually having a slightly worse overall injury severity).
RESULTS: At baseline, both groups exhibited similar scores on WJ-R Letter Word Identification and Calculations, Tower of London number solved, and CVLT-C total correct. Baseline group differences were observed on the CELF-III Formulated Sentences (NBW > LBW) and on the VABS Adaptive Behavior Composite and Socialization subdomain (LBW > NBW). Over 2 years, relative to the NBW group, the LBW group evidenced declines on both WJ-R subtests, CVLT-C total correct, CELF-III Formulated Sentences, and VABS Adaptive Behavior Composite and Socialization.
CONCLUSIONS: Although preliminary in nature due to small sample size, findings suggest a history of LBW influences the recovery trajectory following childhood TBI. Academic and adaptive functioning and verbal memory appeared particularly affected.
摘要：
目的：低出生体重（LBW；低于2500克）是各种神经发育困难的一般危险因素。然而,这些儿童可能仍然更容易受到几年后发生的神经和环境损害。这个前瞻性病例系列报告了患有轻度疾病的儿童，中度,或严重的创伤性脑损伤（TBI）在儿童中期，但谁也出生与出生体重低于2500克。
方法：参与者为14名轻度、中度,或严重的创伤性脑损伤（TBI），其中5名出生体重低于2500克（LBW），9名正常出生体重（NBW）的儿童。所有参与者都来自一项关于儿童TBI的长期认知和行为影响的更大研究，并在年龄上进行匹配。估计社会经济地位(SES)，和TBI的严重程度（NBW儿童实际上具有稍差的整体伤害严重程度）。
结果：在基线时，两组在WJ-R字母单词识别和计算上表现出相似的分数，伦敦塔号码解决了，和CVLT-C总正确。在CELF-III公式句子（NBW>LBW）和VABS适应性行为复合和社交子域（LBW>NBW）上观察到基线组差异。超过2年,相对于NBW组，LBW组证明在两个WJ-R子测试中都有所下降，CVLT-C总正确,CELF-III制定的句子，和VABS适应行为复合和社会化。
结论：尽管由于样本量小，在性质上是初步的，研究结果表明，LBW病史会影响儿童TBI后的恢复轨迹。学术和适应性功能以及言语记忆尤其受到影响。
方法：参与者为14名轻度、中度,或严重的创伤性脑损伤（TBI），其中5名出生体重低于2500克（LBW），9名正常出生体重（NBW）的儿童。所有参与者都来自一项关于儿童TBI的长期认知和行为影响的更大研究，并在年龄上进行匹配。估计社会经济地位(SES)，和TBI的严重程度（NBW儿童实际上具有稍差的整体伤害严重程度）。
结果：在基线时，两组在WJ-R字母单词识别和计算上表现出相似的分数，伦敦塔号码解决了，和CVLT-C总正确。在CELF-III公式句子（NBW>LBW）和VABS适应性行为复合和社交子域（LBW>NBW）上观察到基线组差异。超过2年,相对于NBW组，LBW组证明在两个WJ-R子测试中都有所下降，CVLT-C总正确,CELF-III制定的句子，和VABS适应行为复合和社会化。
结论：尽管由于样本量小，在性质上是初步的，研究结果表明，LBW病史会影响儿童TBI后的恢复轨迹。学术和适应性功能以及言语记忆尤其受到影响。
