Severe immune-mediated drug-induced liver injury linked to ibandronate: a case report.

与伊班膦酸钠相关的严重免疫介导的药物性肝损伤 ： 一例病例报告。

• 影响指数: 30.083
• 发表时间: Nov 2013
• 来源期刊: J Hepatol
• DOI: 10.1016/j.jhep.2013.06.003
• PMID: 23770145
• 文章类型: Case Reports
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Goossens N,Spahr L,Rubbia-Brandt L

关键词: AIH; ALT; AST; Bisphosphonate; CT; DILI; Drug-induced liver injury; HIV; Ibandronate; LFTs; N; RUCAM; Roussel Uclaf Causality Assessment Method; ULN; alanine aminotransferase; aspartate aminotransferase; auto-immune hepatitis; computed tomography; drug-induced liver injury; human immunodeficiency virus; liver function tests; normal; upper limit of normal

Mesh: Adrenal Cortex Hormones; Chemical and Drug Induced Liver Injury / diagnosis drug therapy immunology; Contraindications; Diphosphonates / adverse effects therapeutic use; Female; Humans; Hydroxychloroquine / therapeutic use; Ibandronic Acid; Lupus Erythematosus, Systemic / drug therapy immunology; Middle Aged; Osteoporosis / drug therapy; Steroids / therapeutic use; Treatment Outcome; Withholding Treatment

Abstract

Ibandronate is a widely used bisphosphonate with no previously well documented hepatotoxicity. We report the first case of ibandronate-related hepatotoxicity and, to our knowledge, the first case of immune-mediated drug-induced liver injury (DILI) related to bisphosphonates.

摘要

伊班膦酸盐是一种广泛使用的双膦酸盐，以前没有充分记录的肝毒性。我们报告了首例伊班膦酸钠相关的肝毒性，根据我们的知识，首例与双膦酸盐相关的免疫介导的药物诱导的肝损伤（DILI）。