关键词: Drug-eluting stent Esophageal injury Gastrointestinal hemorrhage Low-dose aspirin Prasugrel

Mesh : Aspirin / adverse effects Diagnosis, Differential Drug-Eluting Stents Esophageal Neoplasms / diagnosis Esophagus / drug effects pathology Humans Intestinal Mucosa / drug effects pathology Male Middle Aged Piperazines / adverse effects Platelet Aggregation Inhibitors / adverse effects Prasugrel Hydrochloride Purinergic P2Y Receptor Antagonists / adverse effects Thiophenes / adverse effects

来  源:   DOI:10.3748/wjg.v17.i35.4048

Abstract:
Dual antiplatelet therapy consisting of low-dose aspirin (LDA) and other antiplatelet medications is recommended in patients with coronary heart disease, but it may increase the risk of esophageal lesion and bleeding. We describe a case of esophageal mucosal lesion that was difficult to distinguish from malignancy in a patient with a history of ingesting LDA and prasugrel after implantation of a drug-eluting stent. Multiple auxiliary examinations were performed to make a definite diagnosis. The patient recovered completely after concomitant acid-suppressive therapy. Based on these findings, we strongly argue for the evaluation of the risk of gastrointestinal mucosal injury and hemorrhage if LDA therapy is required, and we stress the paramount importance of using drug combinations in individual patients.
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