Abstract:
The fundamental concept for the selection of high-performance membrane is based on solute removal capability and biocompatibility. From this principle, the selection guidelines for high-performance membrane are recommended as follows: (1) The currently available products do not provide coverage of the necessary \'balance between solute removal and biocompatibility\' in a single dialyzer for all the dialysis patients. Therefore, it is advisable to choose a high-performance membrane taking into consideration the balance between the solute removal capacity necessary for the patient and the severity of complications that is considered a surrogate marker for biocompatibility. (2) There is an increasing demand in dialysis therapy for new biocompatibility indices such as \'reducing blood pressure variability during dialysis\', \'decreasing oxidative stress\' and \'delaying the onset or progression of complications\'. High-performance membranes developed to address these needs include the ethylene-co-vinyl alcohol copolymer (EVAL) (R) membrane, cellulose triacetate, polymethylmethacrylate, vitamin E-coated polysulfone (PS) membrane, and PS membrane hemodiafiltration filter.
摘要:
选择高性能膜的基本概念是基于溶质去除能力和生物相容性。从这个原则来看,高性能膜的选择指南建议如下:(1)目前可用的产品没有为所有透析患者提供单一透析器中溶质去除和生物相容性之间的必要平衡。因此,考虑到患者所需的溶质去除能力和并发症的严重程度之间的平衡,建议选择高性能的膜,这被认为是生物相容性的替代标记。(2)透析治疗对新的生物相容性指标的需求不断增加,例如“减少透析期间的血压变异性”,“降低氧化应激”和“延迟并发症的发生或进展”。为满足这些需求而开发的高性能膜包括乙烯-共-乙烯醇共聚物(EVAL)(R)膜,三醋酸纤维素,聚甲基丙烯酸甲酯,维生素E涂层聚砜(PS)膜,和PS膜血液透析滤过过滤器。