Mesh : Basic Helix-Loop-Helix Transcription Factors / metabolism Brain / pathology Brain Neoplasms / complications pathology surgery Child, Preschool Epilepsy / etiology surgery Female Glial Fibrillary Acidic Protein / metabolism Glioma / complications pathology surgery Humans Immunohistochemistry Magnetic Resonance Imaging Mitotic Index Nerve Tissue Proteins / metabolism Oligodendrocyte Transcription Factor 2 S100 Proteins / metabolism Seizures / etiology Stem Cells / pathology Tomography, X-Ray Computed Treatment Outcome

来  源:   DOI:10.1007/s10014-010-0274-8

Abstract:
We report a rare case of epileptogenic glioma composed of glial progenitor cells that differentiated into an astrocytic and oligodendrocytic tumor. This 4-year-old girl presented with a 1-year history of complex partial seizure. MR scan showed a mass in the left temporal lobe with a cyst and a contrast-enhanced component. Subtotal resection of the tumor was achieved. Histological examination revealed that the tumor exhibited low cellularity composed of astrocytic and oligodendrocytic components, as well as low mitotic activity (MIB-1 = 1%). Immunohistochemical examination revealed GFAP positivity within the astrocytic cells, olig2 positivity within the oligodendrocytic cells, and S100 positivity in both cell types. MAP2 and CD34 were negative, and neurofilament was only positive in preexisting neurons. The pathological diagnosis was epileptogenic glioma (grade I) composed of glial progenitor cells. The postoperative course has been uneventful with good seizure control for 3 years.
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