PDF(Pubmed)
Abstract：
Emerging reports on the organization of the different hormone-secreting cell types (alpha, glucagon; beta, insulin; and delta, somatostatin) in human islets have emphasized the distinct differences between human and mouse islets, raising questions about the relevance of studies of mouse islets to human islet physiology. Here, we examine the differences and similarities between the architecture of human and mouse islets. We studied islets from various mouse models including ob/ob and db/db and pregnant mice. We also examined the islets of monkeys, pigs, rabbits and birds for further comparisons. Despite differences in overall body and pancreas size as well as total beta-cell mass among these species, the distribution of their islet sizes closely overlaps, except in the bird pancreas in which the delta-cell population predominates (both in singlets and clusters) along with a small number of islets. Markedly large islets (>10,000 mum(2)) were observed in human and monkey islets as well as in islets from ob/ob and pregnant mice. The fraction of alpha-, beta- and delta-cells within an islet varied between islets in all the species examined. Furthermore, there was variability in the distribution of alpha- and delta-cells within the same species. In summary, human and mouse islets share common architectural features that may reflect demand for insulin. Comparative studies of islet architecture may lead to a better understanding of islet development and function.
摘要：
关于不同激素分泌细胞类型的组织的新报告(α，胰高血糖素;β,胰岛素；和三角洲，生长抑素）在人胰岛中强调了人和小鼠胰岛之间的明显差异，提出了有关小鼠胰岛研究与人类胰岛生理学的相关性的问题。这里,我们研究了人类和小鼠胰岛结构之间的差异和相似性。我们研究了来自各种小鼠模型的胰岛，包括ob/ob和db/db和怀孕小鼠。我们还检查了猴子的胰岛，猪,兔子和鸟类作进一步比较。尽管这些物种的整体身体和胰腺大小以及总β细胞质量存在差异，它们的胰岛大小分布紧密重叠，除了在鸟类胰腺中，三角洲细胞群占主导地位（单峰和簇）以及少量的胰岛。在人和猴胰岛以及ob/ob和怀孕小鼠的胰岛中观察到明显大的胰岛(>10,000mum(2))。α-的分数，在所有检查的物种中，胰岛内的β细胞和δ细胞在胰岛之间变化。此外，在同一物种中，α和δ细胞的分布存在差异。总之,人类和小鼠胰岛具有共同的建筑特征，可能反映了对胰岛素的需求。胰岛结构的比较研究可能会导致对胰岛发育和功能的更好理解。
