在自闭症谱系障碍的情况下鉴定的神经元钙传感器 1 突变体的结构和功能缺陷。
Mesh : Amino Acid Substitution / genetics Animals Autistic Disorder / genetics Calcium / pharmacology Calcium Signaling / drug effects Cell Membrane / drug effects metabolism Humans Interleukin-1 Receptor Accessory Protein / metabolism Intracellular Space / drug effects metabolism Magnetic Resonance Spectroscopy Mice Mutant Proteins / metabolism Mutation / genetics Neuronal Calcium-Sensor Proteins / chemistry genetics metabolism Neuropeptides / chemistry genetics metabolism Protein Binding / drug effects Protein Transport / drug effects Structure-Activity Relationship trans-Golgi Network / drug effects metabolism
来 源:
DOI:10.1371/journal.pone.0010534
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