PDF(Pubmed)
Abstract：
People with narcolepsy often have episodes of cataplexy, brief periods of muscle weakness triggered by strong emotions. Many researchers are now studying mouse models of narcolepsy, but definitions of cataplexy-like behavior in mice differ across labs. To establish a common language, the International Working Group on Rodent Models of Narcolepsy reviewed the literature on cataplexy in people with narcolepsy and in dog and mouse models of narcolepsy and then developed a consensus definition of murine cataplexy. The group concluded that murine cataplexy is an abrupt episode of nuchal atonia lasting at least 10 seconds. In addition, theta activity dominates the EEG during the episode, and video recordings document immobility. To distinguish a cataplexy episode from REM sleep after a brief awakening, at least 40 seconds of wakefulness must precede the episode. Bouts of cataplexy fitting this definition are common in mice with disrupted orexin/hypocretin signaling, but these events almost never occur in wild type mice. It remains unclear whether murine cataplexy is triggered by strong emotions or whether mice remain conscious during the episodes as in people with narcolepsy. This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy.
摘要：
发作性睡病的人经常有猝倒发作，强烈情绪引发的短暂肌肉无力。许多研究人员现在正在研究发作性睡病的小鼠模型，但是小鼠猝倒样行为的定义在实验室中有所不同。建立共同的语言，嗜睡症啮齿动物模型国际工作组回顾了有关嗜睡症患者以及犬和小鼠嗜睡症模型中猝倒的文献,然后制定了鼠类猝倒的一致定义.该小组得出的结论是，鼠类猝倒是一种持续至少10秒的突发性神经张力障碍。此外,θ活动在发作期间主导脑电图，和录像记录了不动。为了区分猝倒发作和短暂觉醒后的REM睡眠，至少40秒的清醒必须在情节之前。符合此定义的猝倒在食欲素/降肌动素信号中断的小鼠中很常见，但是这些事件在野生型小鼠中几乎从未发生过。尚不清楚鼠猝倒是由强烈的情绪引发，还是像发作性睡病患者一样，小鼠在发作期间是否保持意识。这个工作定义为小鼠猝倒提供了有益的见解，并且应该在未来的研究中使用发作性睡病的小鼠模型对猝倒进行客观和准确的比较。
