Mesh ： Adult Blood Proteins Diagnosis, Differential Endocardium / pathology Eosinophil Granule Proteins Eosinophils / immunology Fatal Outcome Heart Diseases / diagnosis Humans Hypereosinophilic Syndrome / diagnosis therapy Immunosuppressive Agents / therapeutic use Interferon-alpha / therapeutic use Leukocyte Count Male Oral Ulcer / diagnosis therapy Penile Diseases / diagnosis therapy Ribonucleases / blood Skin Ulcer / diagnosis Splenectomy

来  源：   DOI：10.1016/j.jaci.2003.10.051   PDF(Sci-hub)

Abstract：
Persistent peripheral blood eosinophilia can be associated with a variety of diseases, ranging from parasitic infection to gastrointestinal disease to vasculitis to the hypereosinophilic syndrome (HES). Mucosal ulcerations are a variant presentation of the HES that appear to be markers for a mutation that characterizes a subgroup of patients with HES responsive to treatment with imatinib mesylate. We present a patient with peripheral blood eosinophilia and severe recurrent mucosal ulcers and discuss his presentation in the context of new information about the evaluation, disease progression, and treatment of HES.
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