%0 Case Reports
%T Hypereosinophilic syndrome: case presentation and update.
%A Leiferman KM
%A Gleich GJ
%J J Allergy Clin Immunol
%V 113
%N 1
%D Jan 2004
%M 14713907
%F 14.29
%R 10.1016/j.jaci.2003.10.051
%X Persistent peripheral blood eosinophilia can be associated with a variety of diseases, ranging from parasitic infection to gastrointestinal disease to vasculitis to the hypereosinophilic syndrome (HES). Mucosal ulcerations are a variant presentation of the HES that appear to be markers for a mutation that characterizes a subgroup of patients with HES responsive to treatment with imatinib mesylate. We present a patient with peripheral blood eosinophilia and severe recurrent mucosal ulcers and discuss his presentation in the context of new information about the evaluation, disease progression, and treatment of HES.