Mesh : Acute Disease Adult Anti-Allergic Agents / administration & dosage pharmacology Anti-Inflammatory Agents / administration & dosage Arylsulfonates / administration & dosage pharmacology Drug Administration Schedule Drug Therapy, Combination Eosinophils / drug effects Female Humans Interleukin-4 / antagonists & inhibitors Myocarditis / blood drug therapy immunology pathology Prednisolone / administration & dosage Sulfonium Compounds / administration & dosage pharmacology Th2 Cells / drug effects immunology Time Factors

来  源:   DOI:10.1007/s10380-002-0689-2   PDF(Sci-hub)

Abstract:
We encountered a 44-year-old woman with acute eosinophilic myocarditis that showed positive immunostaining for interleukin-4 in the area of marked infiltration of eosinophils into the myocardium. When prednisolone alone proved ineffective, supplementary treatment with suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, improved the patient\'s inflammation, reduced the level of cardiac enzymes, and allowed for a reduction in corticosteroid dosage without any adverse effects.
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