Abstract：
Spermicides have long been used for vaginal contraception. Quinine was the prototype membrane-active drug used as a vaginal spermicide. Subsequently, propranolol, in both racemic and D-isomeric forms, has been shown to be a powerful inhibitor of sperm motility. The transmembrane migration ratio method was used to quantify the effects of various drugs with membrane stabilizing activity such as propranolol on sperm motility in vitro. Preliminary data from a clinical trial suggests that propranolol tablets used as a vaginal spermicide produce a pregnancy rate of between 3-4/100 women-years in a fertile population. Propranolol is extensively absorbed from the vagina since systolic blood pressure fell below baseline values and plasma concentrations were higher after vaginal administration than after oral administration. Pulse rates also declined. The clinical implications of these studies are discussed.
摘要：
杀精剂长期用于阴道避孕。奎宁是用作阴道杀精子剂的原型膜活性药物。随后，普萘洛尔,外消旋和D-异构形式，已被证明是精子活力的强大抑制剂。使用跨膜迁移比方法来量化具有膜稳定活性的各种药物，例如普萘洛尔对体外精子运动的影响。临床试验的初步数据表明，普萘洛尔片用作阴道杀精子剂在可育人口中产生3-4/100妇女-年的妊娠率。普萘洛尔从阴道广泛吸收，因为收缩压低于基线值，并且阴道给药后的血浆浓度高于口服给药后。脉搏率也下降了。讨论了这些研究的临床意义。
