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Abstract：
Understanding how current chemotherapeutic modalities induce apoptosis is critical to designing better anti-cancer agents. This review is concerned with how pharmacological agents induce tumor cell apoptosis in a cell cycle-dependent manner. Recent experiments demonstrate that expression of several apoptotic regulatory proteins (such as Bcl-2, Bax, p53, and Survivin) are differentially regulated according to the phases of the cell cycle. This cell cycle-dependent regulation in turn contributes to increased drug sensitivity in different phases of the cell cycle. It is therefore likely that the cell cycle-dependent expression of cell death proteins plays a role in regulating chemosensitivity and apoptotic commitment of human tumor cells.
摘要：
了解当前的化疗方式如何诱导细胞凋亡对于设计更好的抗癌剂至关重要。这篇综述涉及药理学药物如何以细胞周期依赖性方式诱导肿瘤细胞凋亡。最近的实验表明，几种凋亡调节蛋白（如Bcl-2，Bax，p53和Survivin）根据细胞周期的阶段而受到差异调节。这种细胞周期依赖性调节又有助于在细胞周期的不同阶段增加药物敏感性。因此，细胞死亡蛋白的细胞周期依赖性表达可能在调节人类肿瘤细胞的化学敏感性和凋亡承诺中起作用。
