{Reference Type}: Journal Article
{Title}: Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review).
{Author}: Smith DM;Gao G;Zhang X;Wang G;Dou QP;
{Journal}: Int J Mol Med
{Volume}: 6
{Issue}: 5
{Year}: Nov 2000
{Factor}: 5.314
{DOI}: 10.3892/ijmm.6.5.503
{Abstract}: Understanding how current chemotherapeutic modalities induce apoptosis is critical to designing better anti-cancer agents. This review is concerned with how pharmacological agents induce tumor cell apoptosis in a cell cycle-dependent manner. Recent experiments demonstrate that expression of several apoptotic regulatory proteins (such as Bcl-2, Bax, p53, and Survivin) are differentially regulated according to the phases of the cell cycle. This cell cycle-dependent regulation in turn contributes to increased drug sensitivity in different phases of the cell cycle. It is therefore likely that the cell cycle-dependent expression of cell death proteins plays a role in regulating chemosensitivity and apoptotic commitment of human tumor cells.