■已发现代谢重编程是肿瘤的典型特征。肝细胞癌(HCC),高发病率和死亡率的癌症,其代谢重编程相关机制已被广泛研究。我们的研究旨在确定HCC代谢重编程研究的热点和前沿,并为HCC代谢的未来科学研究和决策提供指导。
■关于HCC的代谢重编程的相关研究来自截至2023年11月的WebofScienceCoreCollection(WoSCC)数据库。R中的参考文献工具用于科学计量分析和可视化。
■从2011年到2023年,从WoSCC总共获得了575种符合既定标准的出版物。这些出版物涉及37个国家的3,904名研究人员和948个组织,研究的年均增长率为39.11%。这些研究发表在233种期刊上,癌症(n=29)排名第一,其次是肿瘤学前沿(n=20)和国际分子科学杂志(n=19)。排名前十的期刊占575项研究的26%。最多产的作者是王军(n=14),LiY(n=12),和刘J(n=12)。出版物最多的国家是中国,其次是美国,意大利,和法国。复旦大学的研究成果比例最高,为15.48%(n=89)。AllyA\在Cell中的论文引用次数最多。共分析了1,204个关键词,以“糖酵解”等趋势主题,“\”肿瘤微环境,\"\"Warburg效应,“\”线粒体,\"\"缺氧,\"等。共现网络和聚类分析揭示了关键词之间的关系,作者,出版物,和期刊。此外,阐明了各国在这一领域的密切合作。
■本文献计量和视觉分析深入研究了2012年至2023年之间与HCC中代谢重编程有关的研究,阐明了该领域研究的特点,它已经逐渐从单一的糖脂代谢研究转移到体内整体代谢的整合,指出研究课题的趋势,肿瘤微环境与代谢重编程相互作用的动力学将是未来的研究方向,这为该领域的研究人员提供了HCC预防和治疗计划的蓝图和灵感。
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UNASSIGNED: Metabolic reprogramming has been found to be a typical feature of tumors. Hepatocellular carcinoma (HCC), a cancer with high morbidity and mortality, has been extensively studied for its metabolic reprogramming-related mechanisms. Our study aims to identify the hotspots and frontiers of metabolic reprogramming research in HCC and to provide guidance for future scientific research and decision-making in HCC metabolism.
UNASSIGNED: Relevant studies on the metabolic reprogramming of HCC were derived from the Web of Science Core Collection (WoSCC) database up until November 2023. The bibliometrix tools in R were used for scientometric analysis and visualization.
UNASSIGNED: From 2011 to 2023, a total of 575 publications were obtained from WoSCC that met the established criteria. These publications involved 3,904 researchers and 948 organizations in 37 countries, with an average annual growth rate of 39.11% in research. These studies were published in 233 journals, with Cancers (n = 29) ranking first, followed by Frontiers in Oncology (n = 20) and International Journal of Molecular Sciences (n = 19). The top ten journals accounted for 26% of the 575 studies. The most prolific authors were Wang J (n = 14), Li Y (n = 12), and Liu J (n = 12). The country with the most publications is China, followed by the United States, Italy, and France. Fudan University had the largest percentage of research results with 15.48% (n = 89). Ally A\'s paper in Cell has the most citations. A total of 1,204 keywords were analyzed, with the trend themes such as \"glycolysis,\" \"tumor microenvironment,\" \"Warburg effect,\" \"mitochondria,\" \"hypoxia ,\" etc. Co-occurrence network and cluster analysis revealed the relationships between keywords, authors, publications, and journals. Moreover, the close collaboration between countries in this field was elucidated.
UNASSIGNED: This bibliometric and visual analysis delves into studies related to metabolic reprogramming in HCC between 2012 and 2023, elucidating the characteristics of research in this field, which has gradually moved away from single glycolipid metabolism studies to the integration of overall metabolism in the body, pointing out the trend of research topics, and the dynamics of the interaction between the tumor microenvironment and metabolic reprogramming will be the future direction of research, which provides blueprints and inspirations for HCC prevention and treatment programs to the researchers in this field.
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