背景许多国家的献血者(BD)中的梅毒有所增加。Aimwe旨在描述法国BD的梅毒血清阳性趋势,确定危险因素,并评估非热联症测试(NTT)是否可以定义从梅毒中恢复超过1年的BD。方法分析涵盖2007年至2022年期间和45,875,939次捐赠。在2022年的474名BD梅毒阳性患者中,有429人接受了NTT的额外调查。梅毒的病史是在捐赠后的访谈中获得的,或者是根据重复捐赠者的血清学结果获得的。结果在2021年之前,阳性率保持稳定(平均:1.18/10000捐款,范围:1.01-1.38)。2022年观察到增长率增加(1.74/10,000;p=0.02)。在整个学习期间,男性BD的患病率是女性BD的2.2倍(2022年为4.1倍).具有确定的危险因素的男性与男性发生性关系的比例从2007年的16.7%增加到2022年的64.9%。基于NTT,2022年血清呈阳性的捐赠者中有79人(18%)被归类为前一年感染。其中30人有梅毒病史。在过去的3年中都有感染。在测试前梅毒<12个月的七个捐赠者中,1例NTT滴度≥8,3例1~4,3例阴性.结论梅毒血清阳性在2022年BD中显著增加,主要在男性中,特别是MSM。现有数据不允许对NTT进行适当评估,以区分最近和过去的感染。
BackgroundSyphilis in blood donors (BD) has increased in many countries.AimWe aimed to describe trends in syphilis seroposivity in BD in France, to identify risk factors and assess if a non-treponemic test (NTT) could define BD having recovered from syphilis for more than 1 year.MethodsThe analysis covered the period 2007 to 2022 and 45,875,939 donations. Of the 474 BD syphilis-positive in 2022, 429 underwent additional investigations with an NTT. History of syphilis was obtained at the post-donation interview or based on serology results for repeat donors.ResultsUntil 2021, positivity rates remained stable (mean: 1.18/10,000 donations, range: 1.01-1.38). An increased rate was observed in 2022 (1.74/10,000; p = 0.02). Over the whole study period, prevalence was 2.2 times higher in male than in female BD (4.1 times higher in 2022). The proportion of males with an identified risk factor who have sex with men increased from 16.7% in 2007 to 64.9% in 2022. Based on NTT, 79 (18%) of the donors who were seropositive in 2022 were classified as having been infected in the previous year. History of syphilis was available for 30 of them. All had an infection within the previous 3 years. Among seven donors with a syphilis < 12 months before testing, one had an NTT titre ≥ 8, three a titre between 1 and 4, three were negative.ConclusionSyphilis seropositivity increased considerably in BDs in 2022, mostly in males, notably MSM. Available data did not allow appropriate evaluation of the NTT to distinguish recent from past infection.