目的:使用大鼠模型,我们调查了多学科康复的效果,包括有氧训练和药膏,在ROM上,vWF,VEGF含量,关节挛缩大鼠股动脉血流动力学。
方法:将44只Wistar大鼠分为正常对照组(NC,八只大鼠)和实验组(EG)。采用外固定器建立EG组大鼠关节挛缩模型。固定器移除后,32只大鼠进一步分为MC,SC,RE,和SR组(n=8)。在42天的干预前后,ROM,vWF,VEGF,PS,ED,使用X射线成像测量RI,ELISA,还有彩色多普勒超声,分别。
结果:移除固定器后,EG组的ROM低于NC组(p<0.01)。干预之后,SR的ROM,RE,SC组有所改善。SR组的ROM达到了NC组的类似值。SR组vWF和VEGF水平低于MC组,SC,和RE组(p<0.05),与NC组相似。SR和RE组的PS值高于MC和SC组。SR组的RI值高于NC和MC组。
结论:本研究采用多学科康复治疗可协同治疗关节挛缩。它改进了关节的ROM,降低vWF和VEGF的含量,改善股动脉血流动力学.
OBJECTIVE: Using a rat model, we investigated the effect of multidisciplinary rehabilitation, including aerobic training and ointment, on the ROM, vWF, VEGF content, and femoral artery hemodynamics in rats with joint contracture.
METHODS: A total of 44 Wistar rats were divided into the normal control group (NC, eight rats) and the experimental group (EG). A joint contracture model was established for the rats in the EG group by an external fixator. After fixator removal, 32 rats are further divided into the MC, SC, RE, and SR groups (n = 8). Before and after the 42 day intervention, the ROM, vWF, VEGF, PS, ED, and RI were measured using X-ray imaging, ELISA, and color Doppler ultrasound, respectively.
RESULTS: After fixator removal, ROM for EG group was lower than that of the NC group (p < .01). After the intervention, ROM for the SR, RE, and SC groups was improved. The ROM for the SR group reached a similar value for NC group. vWF and VEGF levels in SR group were lower than in the MC, SC, and RE groups (p < .05), and had a similar value to the NC groups. PS value for SR and RE groups was higher than the MC and SC groups. The RI value for SR group was higher than that of NC and MC groups.
CONCLUSIONS: Multidisciplinary rehabilitation used in this study can treat joint contracture synergistically. It improves the ROM of the joint, reduces the content of vWF and VEGF, and improves the femoral artery hemodynamics.