目的:这项前瞻性队列研究的目的是评估种植体周围表型(PPh)对种植体周围疾病严重程度的影响以及非手术机械治疗(NSMT)的结果,以及钙卫蛋白(CLP)和MMP-8(基质金属蛋白酶-8)水平。
方法:纳入39例患者的77个植入物。植入物被归类为第1组(植入物周围粘膜炎),第2组(种植体周围炎)。基线(0。月-PrT)临床参数(PD,GI,PI,防喷器,CAL)和影像学记录骨丢失,并收集种植体周围泪液(PICF)样本。采用各种仪器和方法来评估PPh成分(粘膜厚度,上肌组织高度,角化粘膜)和种植体周围附着粘膜(AM)。将NSMT应用于患病的植入部位。通过在治疗后第6个月(PT)取PICF样品再次评估所有临床参数。在从两组获得的PICF样本中,使用ELISA测试评估MMP-8和CLP水平。
结果:PrT-PD,PrT-GI,第2组的PrT-CAL和PrT-BOP百分比值显著高于第1组。PrT-PD,在薄生物型植入物中,PrTPI评分显著较高。在瘦生物型中,PPh和AM的所有成分均显着降低。两组MMP-8和CLP的时间依赖性变化均有统计学意义(p<0.05)。当评估薄和厚生物型与生化参数之间的关系时,PrT-PT的变化没有显着差异(p>0.05)。
结论:PPh在影响种植体周围疾病的严重程度中起作用。然而,表型对NSMT结局的影响在两组中相似.
结论:计划植入手术时应考虑PPh。
OBJECTIVE: The purpose of this prospective cohort study is to evaluate the effect of peri-implant phenotype (PPh) on the severity of peri-implant diseases and the results of non-surgical mechanical treatment (NSMT), along with calprotectin (CLP) and MMP-8(matrix metalloproteinase-8) levels.
METHODS: 77 implants from 39 patients were included. The implants were categorized Group-1(peri-implant mucositis), Group-2(peri-implantitis).Baseline (0. Month-PrT) clinical parameters (PD, GI, PI, BOP, CAL) and radiographic bone loss were documented, and peri-implant crevicular fluid (PICF) samples were collected. Various intruments and methodologies were employed to assess PPh components (mucosa thickness, supracrestal tissue height, keratinized mucosa) and peri-implant attached mucosa (AM). NSMT was applied to diseased implant sites. All clinical parameters were reassessed again by taking PICF samples at the 6th month-after treatment (PT). In PICF samples obtained from both groups, MMP-8 and CLP levels were evaluated using the ELISA test.
RESULTS: PrT-PD,PrT-GI,PrT-CAL and PrT-BOP percentage values in Group-2 were significantly higher than Group-1.PrT-PD,PrTPI scores are significantly higher in thin biotype implants. All components of the PPh and AM were significantly lower in thin biotype. Intra-group time-dependent changes of MMP-8 and CLP were significant in both groups (p < 0.05). When the relationship between thin and thick biotype and biochemical parameters was evaluated, the change in PrT-PT didn\'t show a significant difference (p > 0.05).
CONCLUSIONS: PPh plays a role in influencing the severity of peri-implant diseases. However, the impact of phenotype on NSMT outcomes was similar in both groups.
CONCLUSIONS: The PPh should be considered when planning implant surgery.