■空间频率域成像(SFDI)应用图案化的近红外照明来量化表面下组织的光学特性。眼周区域由于其复杂的眼附件解剖结构而独特。尽管SFDI已成功应用于相对平坦的体内组织,具有显著高度变化和曲率的区域可能导致光学特性不准确。
■我们表征了眼周区域对SFDI成像可靠性的几何影响。
■SFDI用于通过沿感兴趣区域(ROI)捕获图像来测量铸造面部组织模拟体模中眼周区域的减小的散射系数(μs\')和吸收系数(μa):下时间象限(ITQ),下鼻象限(INQ),上颞叶象限(STQ),中央眼睑边缘(CEM),鼻端外侧鼻桥(RLNB),和前额(FH)。将幻影放在下巴支架上,从“正面”或“侧面轮廓”位置成像9次,体模的平坦背部被测量了15次。
■在比较ITQ时,铸造面部幻像的测量μa和μs'是准确的,INQ,STQ,和FH到其平坦的后表面。ITQ的配对t检验,INQ,STQ,FHμa和μs'得出的结论是,没有足够的证据表明成像方向会影响测量精度。极端地形变化区域,即,CEM和RLNB,确实在测量的光学性质上表现出差异。
■我们是第一个使用实体组织模拟面部体模评估沿眼周区域进行宽视场成像的几何含义的人。结果表明,ITQ,INQ,STQ,广义面的FH对SFDI测量精度的影响最小。地形变化加剧的地区表现出测量变异性。设备和面部定位似乎没有偏差测量。这些发现证实了在沿着眼周区域测量光学特性时仔细选择ROI的需要。
UNASSIGNED: Spatial frequency domain imaging (SFDI) applies patterned near-infrared illumination to quantify the optical properties of subsurface tissue. The periocular region is unique due to its complex ocular adnexal anatomy. Although SFDI has been successfully applied to relatively flat in vivo tissues, regions that have significant height variations and curvature may result in optical property inaccuracies.
UNASSIGNED: We characterize the geometric impact of the periocular region on SFDI imaging reliability.
UNASSIGNED: SFDI was employed to measure the reduced scattering coefficient ( μ s \' ) and absorption coefficient ( μ a ) of the periocular region in a cast facial tissue-simulating phantom by capturing images along regions of interest (ROIs): inferior temporal quadrant (ITQ), inferior nasal quadrant (INQ), superior temporal quadrant (STQ), central eyelid margin (CEM), rostral lateral nasal bridge (RLNB), and forehead (FH). The phantom was placed on a chin rest and imaged nine times from an \"en face\" or \"side profile\" position, and the flat back of the phantom was measured 15 times.
UNASSIGNED: The measured μ a and μ s \' of a cast facial phantom are accurate when comparing the ITQ, INQ, STQ, and FH to its flat posterior surface. Paired t tests of ITQ, INQ, STQ, and FH μ a and μ s \' concluded that there is not enough evidence to suggest that imaging orientation impacted the measurement accuracy. Regions of extreme topographical variation, i.e., CEM and RLNB, did exhibit differences in measured optical properties.
UNASSIGNED: We are the first to evaluate the geometric implications of wide-field imaging along the periocular region using a solid tissue-simulating facial phantom. Results suggest that the ITQ, INQ, STQ, and FH of a generalized face have minimal impact on the SFDI measurement accuracy. Areas with heightened topographic variation exhibit measurement variability. Device and facial positioning do not appear to bias measurements. These findings confirm the need to carefully select ROIs when measuring optical properties along the periocular region.