目的:本研究旨在评估甲状腺乳头状癌(PTC)患者中脂质运载蛋白2(LCN2)的表达,并将其与多结节性甲状腺肿(MNG)进行比较。我们还研究了LCN2表达与临床病理特征之间的相关性。
方法:这项回顾性研究包括63名接受手术治疗的成人乳头状癌患者和65名成人MNG患者。年龄,性别,物理,放射学和组织病理学检查,从医院记录中提取患者的手术数据。尺寸,组织学亚型,胶囊侵入,多焦点,甲状腺外延伸(ETE),淋巴结转移(LNM),从PTC患者的最终组织病理学报告中记录肿瘤的免疫组织化学(IHC)研究。在LCN2表达方面比较患者组。还评估了PTC患者LCN2表达与临床病理和其他IHC参数之间的关系。
结果:PTC组LCN2表达明显高于对照组。LCN2表达与多灶性疾病的存在之间没有显着相关性,囊侵犯,血管浸润,ETE,和LNM。LCN2与人骨髓内皮细胞标志物-1(HBME-1)表达呈中度正相关,然而,LCN2与细胞角蛋白-19(CK19)无相关性,CD56和半乳糖凝集素-3。
结论:LCN2表达可能是鉴别甲状腺良性和恶性病变的有用生物标志物;然而,其表达模式可能与PTC的临床病理特征无关,应在更大临床样本的进一步研究中进行研究.
OBJECTIVE: The present study aimed to assess Lipocalin-2 (LCN2) expression in patients with papillary thyroid cancer (PTC) and to compare it with multinodular goitre (MNG). We also investigated the correlation between LCN2 expression and clinicopathologic characteristics.
METHODS: This retrospective study included 63 surgically treated adult patients with papillary carcinoma and 65 adult patients with a MNG. Age, gender, physical, radiological and histopathological examinations, and surgical data of the patients were extracted from the hospital records. Size, histological subtype, capsule invasion, multifocality, extrathyroidal extension (ETE), lymph node metastasis (LNM), and immunohistochemical (IHC) studies of the tumour were recorded from the final histopathological reports of patients with PTC. The patient groups were compared in terms of LCN2 expression. The relationships between LCN2 expression and clinicopathological and other IHC parameters were also evaluated in patients with PTC.
RESULTS: LCN2 expression was significantly higher in the PTC group than in the control group. No significant correlation was demonstrated between LCN2 expression and the presence of multifocal disease, capsular invasion, vascular invasion, ETE, and LNM. There was a moderate positive correlation between LCN2 and human bone marrow endothelial cell marker-1 (HBME-1) expressions, however, no correlation was found between LCN2 and cytokeratin-19 (CK19), CD56, and galectin-3.
CONCLUSIONS: LCN2 expression may be a useful biomarker in differentiating benign and malignant lesions of the thyroid gland; however, its expression pattern may not be associated with clinicopathologic characteristics of the PTC and should be investigated in further studies with larger clinical samples.