■移植后淋巴增生性疾病(PTLD),一个术语,包括移植后发生的各种恶性肿瘤,可能是最具破坏性的移植并发症之一。虽然在护理方面取得了重大进展,尤其是在2012年有里程碑意义的PTLD-1试验后,关于PTLD的住院情况和住院情况随时间变化的信息很少.
■这项回顾性队列研究使用国家住院患者样本来确定2009年至2018年发生的PTLD住院情况。我们提取了主要或次要诊断为PTLD的住院数据,并检查了一系列变量,包括年龄,性别,种族,医院类型,医院位置,和性格状态。我们还收集了医院地区的数据,家庭收入中位数,保险状况,和床的大小。
■从2009年到2019年,住院人数在统计上显着增加,并且在研究期间住院率增加。高血压,电解质失衡,肾功能衰竭,贫血是最常见的合并症之一。我们发现死亡率上升,但这没有统计学意义。
我们的研究提供了近10年PTLD住院率变化的见解。显示住院人数和合并症报告增加。
UNASSIGNED: Posttransplant lymphoproliferative disorder (PTLD), a term that encompasses a wide array of malignancies that occur after transplant, can be one of the most devastating transplant complications. While there have been major advancements in care, especially after the landmark PTLD-1 trial in 2012, there is a paucity of information on hospitalizations for PTLD and the changes in
hospitalizations over time.
UNASSIGNED: This retrospective cohort study used the National Inpatient Sample to identify hospitalizations for PTLD that occurred between 2009 and 2018. We extracted data for hospitalizations with a primary or secondary diagnosis of PTLD and examined a range of variables, including age, gender, race, hospital type, hospital location, and disposition status. We also collected data on hospital region, median household income, insurance status, and bed size.
UNASSIGNED: There was a statistically significant increase in the number of
hospitalizations from 2009 to 2019 and an increasing rate of
hospitalizations over the study period. Hypertension, electrolyte imbalances, renal failure, and anemia were among the most common comorbidities. We found an increased mortality rate, but this was not statistically significant.
UNASSIGNED: Our study provides insight into the changes in
hospitalizations for PTLD over nearly a decade, showing an increase in
hospitalizations and reports of comorbidities.