背景:多领域干预对促进健康衰老具有明显的益处,但维持长期收益的自我授权战略仍然遥不可及。
目的:本研究评估了参与数字体感舞蹈游戏对作为主要结果的大脑意象变化和作为与健康衰老相关的次要结果的其他身体和心理健康指标的影响。
方法:在2020年8月31日至2021年6月27日之间,这项随机对照试验招募了60名55岁以上且最近没有参与数字舞蹈游戏的合格参与者。使用计算机生成的随机化序列以1:1分配参与者,不进行分层,接受数字体感舞蹈游戏训练的干预组(n=30)或对照组(n=30)。匿名代码掩盖了调查人员的干预分配,分配干预措施的个体不参与分析研究数据.干预需要在6个月内每周进行两次30分钟的舞蹈游戏,对照组接受健康老龄化教育。主要结果是大脑意象变化。在基线和6个月随访时测量所有变量,使用t检验和意向治疗分析估计干预效果。
结果:与对照组相比,干预参与者在左壳核的灰质体积(GMV)中具有显着差异的大脑图像(估计值0.016,95%CI0.008至0.024;P<.001),左苍白球的GMV(估计值0.02,95%CI0.006至0.034;P=.004),和左苍白球低频波动的小振幅(估计0.262,95%CI0.084至0.439;P=.004)。此外,干预组小脑VIGMV图像不同(估计值0.011,95%CI0.003~0.02;P=.01).干预组的蒙特利尔认知评估总分也有所改善(估计1.2,95%CI0.27至-2.13;P<0.01),生活质量(估计7.08,95%CI2.35至11.82;P=.004),和工作日坐着的时间(估计-1.96,95%CI-3.33至-0.60;P=0.005)。此外,舞蹈表现与认知表现显著相关(P=0.003),健康状况(P=0.14),弹性(P=0.007),和士气低落(P<.001)。
结论:参与6个月的数字体感舞蹈游戏与涉及体感的多个区域的大脑意象变化有关,电机,视觉,和注意功能,这与健康衰老相关的表型改善是一致的。
背景:ClinicalTrials.govNCT05411042;https://clinicaltrials.gov/study/NCT05411042。
BACKGROUND: Multidomain interventions have demonstrable benefits for promoting healthy aging, but self-empowerment strategies to sustain long-term gains remain elusive.
OBJECTIVE: This study evaluated the effects of digital somatosensory dance game participation on brain imagery changes as primary outcomes and other physical and mental health measures as secondary outcomes related to healthy aging.
METHODS: Between August 31, 2020, and June 27, 2021, this randomized controlled trial recruited 60 eligible participants older than 55 years with no recent engagement in digital dance games. A computer-generated randomization sequence was used to allocate participants 1:1, without stratification, to an intervention group (n=30) who underwent digital somatosensory dance game training or a control group (n=30). An anonymized code masked the intervention allocations from the investigators, and individuals who assigned the interventions were not involved in analyzing the study data. The intervention entailed two 30-minute dance game sessions per week for 6 months, and the control group received healthy aging education. Primary outcomes were brain imagery changes. All variables were measured at baseline and the 6-month follow-up, and intervention effects were estimated using t tests with intention-to-treat analyses.
RESULTS: Compared with the control group, intervention participants had significantly different brain imagery in the gray matter volume (GMV) of the left putamen (estimate 0.016, 95% CI 0.008 to 0.024; P<.001), GMV of the left pallidum (estimate 0.02, 95% CI 0.006 to 0.034; P=.004), and fractional amplitude of low frequency fluctuations of the left pallidum (estimate 0.262, 95% CI 0.084 to 0.439; P=.004). Additionally, the intervention group had different imagery in the cerebellum VI GMV (estimate 0.011, 95% CI 0.003 to 0.02; P=.01). The intervention group also had improved total Montreal Cognitive Assessment scores (estimate 1.2, 95% CI 0.27 to -2.13; P<.01), quality of life (estimate 7.08, 95% CI 2.35 to 11.82; P=.004), and time spent sitting on weekdays (estimate -1.96, 95% CI -3.33 to -0.60; P=.005). Furthermore, dance performance was significantly associated with cognitive performance (P=.003), health status (P=.14), resilience (P=.007), and demoralization (P<.001).
CONCLUSIONS: Digital somatosensory dance game participation for 6 months was associated with brain imagery changes in multiple regions involving somatosensory, motor, visual, and attention functions, which were consistent with phenotypic improvements associated with healthy aging.
BACKGROUND: ClinicalTrials.gov NCT05411042; https://clinicaltrials.gov/study/NCT05411042.