■评估无视网膜病变的糖尿病的光学相干断层扫描血管造影和模式以及闪光视网膜电图的发现和相关性。
■38名糖尿病患者的76只眼以及年龄和性别匹配的对照受试者被纳入研究。中央凹无血管区(FAZ),整个,中央凹,浅表毛细血管丛(SCP)的中央凹和中央凹血管密度,使用光学相干断层扫描血管造影(OCTA)分析了深毛细血管丛(DCP)和脉络膜毛细血管丛(CCP)层。使用Metrovision品牌monpack模型设备评估了模式ERG(pERG)的P50和N95波的振幅和隐含时间以及闪光ERG(fERG)测试的暗视和明视b波和振荡电位(OP)的振幅和隐含时间。
■患者的平均年龄为59.7±7.9[范围43-79]岁。18例(47%)患者为女性,20例(53%)为男性。糖尿病的平均持续时间为7.45±6.2[范围1-20]年。研究对象和对照之间的FAZ面积没有发现显着差异。浅表毛细血管丛(SCP)层的血管密度(VD)值显著降低(全VD,44.7±3.3vs.46.6±3.2%,p=0.01,中央凹VD16.8±6.4vs.24.9±6.1%,p<0.01,旁凹VD45.6±4.5vs.47.1±4.4%,p=0.27,中央凹VD45.5±3.3与47.3±3.1%,分别为p=0.01)在糖尿病组中除旁凹区域外。深层和脉络膜毛细血管丛的VD测量值在两组之间没有显着差异(p>0.05)。ERG测试显示,暗位b波振幅显着降低(130.2±39.3µVvs.163.3±47.8µV,p<0.01)和明视b波振幅(83.2±20.7µVvs.99.6±29.4µV,在糖尿病患者中p<0.01)。明视反应的隐含时间显着延长(28.9±1.3msvs.27.8±2.1ms,患者中p=0.01)。糖尿病组O1至O4组成的所有成分的振荡电位和OP电位的总和均低于对照组(p<0.001)。各组间P50和N95的振幅和隐含时间具有可比性(p>0.05)。相关分析表明,pERG中的N95振幅与OCTA中的浅表血管密度之间呈正相关(r=0.26,p=0.04)。在fERG的明视隐含时间与脉络膜毛细血管密度之间发现负相关(r=-0.27,p=0.03)。
■OCTA显示,随着糖尿病代谢过程的发生,浅表血管密度降低。由于这些结构性变化,较低的暗视和明视振幅,OP振幅降低,并在闪光ERG中获得延长的隐含时间。
UNASSIGNED: To evaluate the findings and the correlation of optical coherence tomography angiography and pattern and flash
electroretinography in diabetes mellitus without retinopathy.
UNASSIGNED: Seventy-six eyes of 38 diabetic patients and age- and gender-matched control subjects were included in the study. The foveal avascular zone (FAZ), whole, foveal, parafoveal and perifoveal vascular densities of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillary plexus (CCP) layers were analyzed using optical coherence tomography angiography (OCTA). The amplitudes and implicit times of P50 and N95 waves of the pattern ERG (pERG) and the amplitudes and implicit times of the scotopic and photopic b-waves and oscillatory potentials (OP) of the flash ERG (fERG) tests were evaluated using the Metrovision brand monpack model device.
UNASSIGNED: The mean age of the patients was 59.7 ± 7.9 [range 43-79] years. Eighteen (47%) of the patients were female and 20 (53%) were male. The mean duration of diabetes was 7.45 ± 6.2 [range 1-20] years. No significant difference in FAZ area was found between study subjects and controls. Vascular density (VD) values of the superficial capillary plexus (SCP) layer were significantly lower (whole VD, 44.7 ± 3.3 vs. 46.6 ± 3.2%, p = 0.01, foveal VD 16.8 ± 6.4 vs. 24.9 ± 6.1%, p < 0.01, parafoveal VD 45.6 ± 4.5 vs. 47.1 ± 4.4%, p = 0.27 and perifoveal VD 45.5 ± 3.3 vs. 47.3 ± 3.1%, p = 0.01, respectively) in the diabetic group except the parafoveal area. VD measurements in deep and choriocapillary plexuses did not significantly differ between the groups (p > 0.05). ERG tests revealed significantly lower scotopic b-wave amplitudes (130.2 ± 39.3 µV vs.163.3 ± 47.8 µV, p < 0.01) and photopic b-wave amplitudes (83.2 ± 20.7 µV vs. 99.6 ± 29.4 µV, p < 0.01) in the diabetic patients. The implicit time of the photopic responses was significantly prolonged (28.9 ± 1.3 ms vs. 27.8 ± 2.1 ms, p = 0.01) in the patients. Oscillatory potentials in all components consisting of O1 to O4 and the sum of the OP potentials were lower in the diabetic group than the control subjects (p < 0.001). The P50 and N95 amplitudes and implicit times were comparable between the groups (p > 0.05). Correlation analysis showed a positive correlation between N95 amplitudes in pERG and the superficial vessel densities in OCTA (r = 0.26, p = 0.04). A negative correlation was found between photopic implicit times in fERG and the choriocapillary vessel densities (r=-0.27, p = 0.03).
UNASSIGNED: OCTA revealed decreased superficial vascular densities with the onset of the metabolic process of diabetes mellitus. As a result of these structural changes, lower scotopic and photopic amplitudes, decreased OP amplitudes, and prolonged implicit times in flash ERG were obtained.