心室复极延长与心血管疾病有关。我们试图研究老年人心室复极延长与轻度认知障碍(MCI)的关系以及潜在的潜在神经病理机制。这项横断面研究纳入了4328名无痴呆参与者(年龄≥65岁;56.8%为女性),他们接受了中国农村地区延缓痴呆和残疾的多领域干预措施的基线检查;其中,989进行了结构性脑磁共振成像(MRI)扫描。QT,QTc,JT,JTc,QRS间期来自12导联心电图。MCI,遗忘型MCI(aMCI),根据Petersen的标准定义非遗忘型MCI(naMCI)。灰质体积(GM),白质,脑脊液,总白质高强度(WMH),脑室周围WMH(PWMH),和深度WMH(DWMH)自动估计。使用逻辑和一般线性回归模型分析数据。延长QT,QTc,JT,和JTc间期与MCI和aMCI的可能性增加显着相关,但与naMCI无关(p<0.05)。在MRI子样本中,QT,QTc,JT,和JTc间隔与较大的WMH和PWMH总体积显着相关(p<0.05),但不是DWMH卷。检测到统计相互作用,因此,仅在有冠心病或无APOEε4等位基因的参与者中,QT和JT间期延长与GM体积减少显着相关(p<0.05)。在一般老年人群中,心室复极延长与MCI和脑微血管病变相关。这是在QT间期延长的老年人中进行认知评估和脑MRI检查的重要性的基础。
Prolonged ventricular repolarization has been associated with cardiovascular disease. We sought to investigate the association of prolonged ventricular repolarization with mild cognitive impairment (MCI) and the potential underlying neuropathological mechanisms in older adults. This cross-sectional study included 4328 dementia-free participants (age ≥ 65 years; 56.8% female) in the baseline examination of the Multidomain INterventions to delay dementia and Disability in rural China; of these, 989 undertook structural brain magnetic resonance imaging (MRI) scans. QT, QTc, JT, JTc, and QRS intervals were derived from 12-lead electrocardiograph. MCI, amnestic MCI (aMCI), and non-amnestic MCI (naMCI) were defined following the Petersen\'s criteria. Volumes of gray matter (GM), white matter, cerebrospinal fluid, total white matter hyperintensities (WMH), periventricular WMH (PWMH), and deep WMH (DWMH) were automatically estimated. Data were analyzed using logistic and general linear regression models. Prolonged QT, QTc, JT, and JTc intervals were significantly associated with an increased likelihood of MCI and aMCI, but not naMCI (p < 0.05). In the MRI subsample, QT, QTc, JT, and JTc intervals were significantly associated with larger total WMH and PWMH volumes (p < 0.05), but not with DWMH volume. Statistical interactions were detected, such that prolonged QT and JT intervals were significantly associated with reduced GM volume only among participants with coronary heart disease or without APOE ε4 allele (p < 0.05). Prolonged ventricular repolarization is associated with MCI and cerebral microvascular lesions in a general population of older adults. This underlies the importance of cognitive assessments and brain MRI examination among older adults with prolonged QT interval.