目的:这项回顾性多中心队列研究旨在研究胚胎移植期间地西泮给药对生殖结局的影响,主要关注活产率。次要结果包括β-hCG阳性率,临床妊娠率,流产率,异位妊娠率,和早产率。
方法:来自5607个胚胎移植的数据,包括465例服用地西泮的病例,进行回顾性分析。该研究包括2015年1月至2022年12月期间来自葡萄牙和西班牙12家诊所的单个囊胚移植。
结果:接受地西泮的患者和未接受地西泮的患者的生殖结局比较没有统计学上的显著差异。β-hCG阳性率(非地西泮与60.8%60.4%地西泮,p=0.92,调整后p=0.32)和临床妊娠率(非地西泮vs.46.2%地西泮,p=0.81,调整后的p=0.11)具有可比性。流产率(地西泮与11.0%9.3%非地西泮,p=0.25,调整后p=0.26)和异位妊娠率(地西泮与0.1%非地西泮,p=0.1,调整后的p=0.20)相似。活产率(非地西泮vs.36.3%35.3%地西泮,p=0.69,调整后p=0.82)和早产率(0.3%非地西泮与0%地西泮,p>0.99,调整后的p=0.99)也没有统计学上的显着差异。
结论:根据结果,胚胎移植期间的地西泮给药对生殖结果没有明显的影响,包括活产率,表明其在增强成功方面的有效性有限。
OBJECTIVE: This retrospective multicenter cohort study aimed to investigate the impact of diazepam administration during embryo transfer on reproductive outcomes, focusing primarily on the live birth rate. Secondary outcomes included the positive beta-hCG rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate, and preterm birth rate.
METHODS: Data from 5607 embryo transfers, encompassing 465 cases with diazepam administration, were retrospectively analyzed. The study included single blastocyst transfers from 12 clinics in Portugal and Spain between January 2015 and December 2022.
RESULTS: Comparison of reproductive outcomes between patients receiving diazepam and those who did not showed no statistically significant differences. Positive beta-hCG rates (60.8% non-
diazepam vs. 60.4%
diazepam, p = 0.92, adjusted p = 0.32) and clinical pregnancy rates (45.6% non-
diazepam vs. 46.2%
diazepam, p = 0.81, adjusted p = 0.11) were comparable. Miscarriage rates (11.0% diazepam vs. 9.3% non-diazepam, p = 0.25, adjusted p = 0.26) and ectopic pregnancy rates (0.9%
diazepam vs. 0.1% non-
diazepam, p = 0.1, adjusted p = 0.20) were similar. Live birth rates (36.3% non-
diazepam vs. 35.3%
diazepam, p = 0.69, adjusted p = 0.82) and prematurity rates (0.3% non-
diazepam vs. 0%
diazepam, p > 0.99, adjusted p = 0.99) also exhibited no statistically significant differences.
CONCLUSIONS: Based on the results, diazepam administration during embryo transfer did not show a discernible impact on reproductive outcomes, including live birth rates, suggesting its limited effectiveness in enhancing success.