背景:子宫内膜异位症与多种体征和症状有关,并可导致不孕,胚胎死亡,甚至流产.尽管子宫内膜异位症的确切发病机制和病因尚不清楚,已经证明它具有慢性炎症性质,血管生成也参与其中。
目的:这篇综述旨在探讨炎症和血管生成在子宫内膜异位症中的作用,并提出针对这些途径的潜在治疗方法。
结果:在促炎细胞因子中,研究表明白细胞介素1β(IL-β),IL-6和肿瘤坏死因子α(TNF-α)在这种情况的发病机理中。除了炎症,血管生成,从先前存在的毛细血管形成新血管,也参与了子宫内膜异位症的发病机制。在血管生成因子中,血管内皮生长因子(VEGF),缺氧诱导因子1α(HIF-1α),转化生长因子β1(TGF-β1),基质金属蛋白酶(MMPs)在子宫内膜异位症的发病机制中更重要。有趣的是,研究表明,炎症和血管生成有一些相似的途径,这些途径有可能成为治疗由这两个过程引起的疾病的靶点。大麻二酚(CBD)是大麻素的非精神活性成员,具有众所周知的显着抗炎和抗血管生成特性。该药物已被证明可以降低IL-1β,IL-6,TNF-α,VEGF,TGFβ,和MMPs在不同的动物模型的疾病。
结论:由于其抗炎和抗血管生成活性,CBD可能是子宫内膜异位症的可能治疗方法,然而,需要进一步的研究。
BACKGROUND: Endometriosis is associated with a wide variety of signs and symptoms and can lead to infertility, embryo death, and even miscarriage. Although the exact pathogenesis and etiology of endometriosis is still unclear, it has been shown that it has a chronic inflammatory nature and angiogenesis is also involved in it.
OBJECTIVE: This review aims to explore the role of inflammation and angiogenesis in endometriosis and suggest a potential treatment targeting these pathways.
RESULTS: Among the pro-inflammatory cytokines, studies have shown solid roles for interleukin 1β (IL-β), IL-6, and tumor necrosis factor α (TNF-α) in the pathogenesis of this condition. Other than inflammation, angiogenesis, the formation of new blood vessels from pre-existing capillaries, is also involved in the pathogenesis of endometriosis. Among angiogenic factors, vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1α (HIF-1α), transforming growth factor β1 (TGF-β1), and matrix metalloproteinases (MMPs) are more essential in the pathogenesis of endometriosis. Interestingly, it has been shown that inflammation and angiogenesis share some similar pathways with each other that could be potentially targeted for treatment of diseases caused by these two processes. Cannabidiol (CBD) is a non-psychoactive member of cannabinoids which has well-known and notable anti-inflammatory and antiangiogenic properties. This agent has been shown to decrease IL-1β, IL-6, TNF-α, VEGF, TGFβ, and MMPs in different animal models of diseases.
CONCLUSIONS: It seems that CBD could be a possible treatment for endometriosis due to its anti-inflammatory and antiangiogenic activity, however, further studies are needed.