目的:本研究旨在评估松质骨矿物质颗粒和10%猪胶原蛋白(含胶原蛋白的脱蛋白牛骨矿物质[DBBM-C];(OCS-BCollagen®[StraumannXenoFlex],NIBEC,韩国)以可模制的块状形式,带或不带插座密封,使用自体游离牙龈移植物(FGG)。
方法:纳入54例患者,随机分为三组:(1)自发愈合(对照组),(2)牙槽嵴保存(ARP)采用DBBM-C(DBBM-C组),和(3)采用用FGG密封的DBBM-C(DBBM-C/FGG组)的ARP。ARP后180天进行骨活检和植入物固定装置放置。锥形束计算机断层扫描,组织学分析,植入物稳定性,并进行了三维体积分析。
结果:在54例患者中,4人因失去随访和骨整合失败而退出。随访期间牙槽骨的变化没有显着差异。在提取后84天至180天之间,DBBM-C和DBBM-C/FGG组的体积保持在牙槽脊以下3mm(0.72±0.80mm,6.05±6.69%),而对照组的体积减少(-0.37±1.31mm,-2.10%±8.37%)(P=0.026)。DBBM-C/FGG组在牙槽骨下方1mm处表现出较少的水平脊吸收(-9.19±5.09mm,提取前和提取后84天之间的-73.67%±32.53%)(P=0.049)。在所有组中,种植体稳定商保持在70以上。
结论:在本研究的局限性内,使用DBBM-C的ARP有和没有插座密封有效地保留了牙槽脊的宽度尺寸,牙槽骨吸收无显著差异。然而,插座密封似乎提高了骨移植物的稳定性和骨质量。
结论:与自发愈合相比,使用DBBM-C治疗ARP似乎有助于容量维持。用FGG密封牙龈可以帮助保持牙槽的宽度。该临床试验在参与者招募和随机化之前未注册。这项研究已在WHOICTRP(https://trialsearch。谁。int/Trial2。aspx?试验ID=KCT0008266)。
OBJECTIVE: This study sought to evaluate the efficacy of cancellous bovine bone mineral granules and 10% porcine collagen (deproteinized bovine bone mineral with collagen [DBBM-C]; (OCS-B Collagen® [Straumann XenoFlex], NIBEC, Korea) in a mouldable block form, with or without socket seal, using autogenous free gingival graft (FGG).
METHODS: Fifty-four patients were included and randomly assigned to one of three groups: (1) spontaneous healing (control group), (2) alveolar ridge preservation (ARP) using DBBM-C (DBBM-C group), and (3) ARP employing DBBM-C sealed with FGG (DBBM-C/FGG group). Bone biopsy and implant fixture placement were performed 180 days after ARP. Cone-beam computed tomography, histological analysis, implant stability, and three-dimensional volumetric analysis were conducted.
RESULTS: Of the 54 patients, 4 dropped out owing to loss of follow-up and osseointegration failure. The changes in alveolar bone during follow-up were not significantly different. Between 84- and 180-day postextraction, the volume of the DBBM-C and DBBM-C/FGG groups was maintained at 3 mm below the alveolar ridge crest (0.72 ± 0.80 mm, 6.05 ± 6.69%), whereas the volume in the control group decreased (-0.37 ± 1.31 mm, -2.10% ± 8.37%) (P = .026). The DBBM-C/FGG group exhibited less horizontal ridge resorption at 1 mm below the alveolar crest (-9.19 ± 5.09 mm, -73.67% ± 32.53%) between preextraction and 84 days postextraction (P = .049). In all groups, the implant stability quotient remained above 70.
CONCLUSIONS: Within the limitations of this study, both ARP using DBBM-C with and without socket sealing effectively preserved the width dimension of the alveolar ridge, with no significant difference in alveolar bone resorption. However, socket sealing appeared to enhance the stability of the bone graft and bone quality.
CONCLUSIONS: The use of DBBM-C for ARP seems to aid in volume maintenance as compared with spontaneous healing. Gingival sealing with an FGG can help maintain the width of the alveolar ridge. This clinical trial was not registered prior to participant recruitment and randomization. This study was registered at WHO ICTRP (https://trialsearch.who.int/Trial2.aspx?TrialID=KCT0008266).