■结核病(TB)是全球死亡的主要原因。以前的研究报告说,结核病易感性可能是由维生素D缺乏引起的,受维生素D受体(VDR)基因多态性的影响。然而,这些结果不一致。因此,我们进行了一项荟萃分析,以研究VDR多态性与TB易感性之间的关联.
■我们系统地搜索了PubMed,Embase,和Medline数据库到12月31日,2022年。制定了纳入和排除标准,以确保HIV阴性人群是目标受试者。然后使用合并的优势比(OR)和95%置信区间(CI)来评估关联的强度,纳入文章的质量采用纽卡斯尔-渥太华量表进行评价。基于亚组和荟萃回归分析评估异质性的潜在来源。
■在我们的荟萃分析中,我们发现VDR基因中的FokI多态性与等位基因和隐性基因型模型中的TB易感性增加相关(ORf与F=1.235,95CI:1.035-1.475;或ffvs.Ff+FF=1.317,95CI:1.005-1.727。基于种族的进一步亚组分析表明,在汉族人群的FokI多态性的所有基因型模型中,与结核病风险相关。荟萃回归分析还表明,种族可能是VDR基因FokI和BsmI多态性异质性的潜在来源。然而,出版年是TaqI多态性异质性的另一个来源。
■总之,发现VDR基因中的FokI多态性会增加HIV阴性人群的结核病风险,整体和亚洲人口。本文的研究结果可以从补充维生素D的角度为结核病的预防提供线索。这在医学和健康领域是一个有争议的话题。
UNASSIGNED: Tuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (VDR) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between VDR polymorphisms and TB susceptibility.
UNASSIGNED: We systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (OR) and 95% confidence interval (CI) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle-Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses.
UNASSIGNED: In our meta-analysis, we found that the FokI polymorphism in the VDR gene was associated with increased TB susceptibility in the allele and recessive genotype models (OR f vs. F = 1.235, 95%CI: 1.035-1.475; OR ff vs. Ff + FF = 1.317, 95%CI: 1.005-1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the VDR gene. However, publication year was another source of heterogeneity for the TaqI polymorphism.
UNASSIGNED: In summary, the FokI polymorphism in the VDR gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health.