■本研究旨在研究七个土耳其榛子(CorylusavellanaL.)基因型的可食用和非可食用部分的抗癌紫杉烷概况。榛子是富含营养和抗氧化剂的健康食品之一。它的定期食用与降低患冠心病和癌症的风险有关。榛子已被描述为产生紫杉烷的植物来源,紫杉烷被广泛用于许多癌症。Türkiye是榛子文化的故乡,拥有自己的品种。研究土耳其榛子基因型不同部位的抗癌紫杉烷概况对于从制药和食品工业的角度显示该植物的潜力和价值很重要。
■在这项研究中,绿叶盖(GLC)和硬壳(HS)(非可食用部分),无皮肤内核(SKs),棕色皮肤(BS),和Kelak²ldak的棕色皮肤内核(BSKs)(可食用部分),Sivri,Tombul,帕拉兹,和卡尔纳卡拉作为标准,使用Ham和SivriYalº作为本地基因型。将每种基因型的五个部分研磨成粉末并消除至小于80目的尺寸。每个部分使用己烷和甲醇提取10-脱乙酰浆果蛋白酶III(10-DABIII),baccatinIII(BACIII),头孢菌素,和紫杉醇分析,三个重复。样品和标准品用乙腈:水梯度法在NOVASpher100苯基-己基C18色谱柱上,用228nm紫外检测器和1.0mL/min流速的高效液相色谱反相系统进行分析。MicrosoftOfficeExcel,2016年,采用Jamovi2.3版的方差分析进行统计和数据分析,连续。
■榛子零件在最高10-DABIII(HamHS,9,15μg/g),BACIII(卡勒恩卡拉BS,7.24μg/g),头孢霉素(SivriYaoll²BSs,6.37μg/g),和紫杉醇(HamBSKs,4.36μg/g)。而HS,BSKs,在所有分析的基因型中,BS富含紫杉烷,SKs,和GLC对于抗癌紫杉烷仍然有限。
■这是第一份报告,揭示了土耳其榛子紫杉烷含量的差异,包括以前未经测试的标准和当地基因型及其部分。基因型和榛子部分之间的显着差异预计将突出食用带有BS的生土耳其榛子的健康益处及其可能用作功能性食品。这些结果为阐明土耳其榛子及其副产品的生物活性潜力提供了更多信息,并为食品和制药行业提供了具有抗癌前景的有希望的资源。
UNASSIGNED: This study aimed to investigate the anticancer taxane profiles of edible and non-edible parts of seven Turkish hazelnut (Corylus avellana L.) genotypes. Hazelnut is one of the healthy foods rich in nutrients and antioxidants. Its regular consumption is associated with a reduced risk of coronary heart disease and cancer. Hazelnut has been described as a plant source that produces
taxanes which are widely used in many cancers. Türkiye is a homeland of hazelnut culture and has its own cultivars. Investigation of anticancer taxane profiles in different parts of Turkish hazelnut genotypes is important to show the potential and value of this plant from the perspective of the pharmaceutical and food industries.
UNASSIGNED: In this study, green leafy covers (GLCs) and hard shells (HSs) (non-edible parts), skinless kernels (SKs), brown-skins (BSs), and brown-skinned kernels (BSKs) (edible parts) of Çakıldak, Sivri, Tombul, Palaz, and Kalınkara as standard and Ham and Sivri Yağlı as local genotypes were used. The five parts of each genotype were ground to powder and eliminated to a size of less than 80 mesh. Each part was extracted using hexane and methanol for 10-deacetylbaccatin III (10-DAB III), baccatin III (BAC III), cephalomannine, and paclitaxel analyses in three replicates. Samples and standards were analyzed by acetonitrile: water gradient method on NOVA Spher 100 Phenyl-Hexyl C18 column inhigh-performance liquid chromatography reverse phase system with 228 nm ultraviolet detector and 1.0 mL/min flow rate. Microsoft Office Excel, 2016, and analysis of variance Jamovi Version 2.3 were used for statistical and data analysis, consecutively.
UNASSIGNED: Hazelnut parts differed to a very high degree from each other in terms of the highest amount of 10- DAB III (Ham HSs, 9,15 μg/g), BAC III (Kalınkara BSs, 7.24 μg/g), cephalomannine (Sivri Yağlı BSs, 6.37 μg/g), and paclitaxel (Ham BSKs, 4.36 μg/g) they contained. While HSs, BSKs, and BSs were rich in
taxanes in all of the analyzed genotypes, SKs, and GLCs remain limited for anticancer
taxanes.
UNASSIGNED: This is the first report that revealed the differences in taxane contents of Turkish hazelnuts including previously untested standard and local genotypes and their parts. Significant differences between genotype and hazelnut parts are expected to highlight the health benefits of consuming raw Turkish hazelnut with BSs and their possible use as a functional food. These results add more information to elucidate the bioactive potential of Turkish hazelnuts and their by-products and provide a promising resource for the food and pharmaceutical industry with an anticancer perspective.