肥胖和2型糖尿病(T2DM)是复杂的代谢紊乱,具有多因素的病因,通常会导致一系列并发症。最近的研究强调了这些疾病对骨骼健康的影响,特别关注硬化蛋白(SOST)的作用,骨代谢不可或缺的蛋白质分子。与健康个体相比,T2DM患者的SOST循环水平升高。这项研究旨在研究居住在科威特的多种族人口中SOST的循环水平,并阐明SOST水平之间的关系。肥胖,T2DM,种族背景。该研究是对居住在科威特的2083人的大型队列的横断面分析。使用骨组多重测定法测量SOST的血浆水平。研究发现,T2DM患者的SOST水平显着增加(1008.3pg/mL,IQR-648)与非糖尿病个体(710.6pg/mL,IQR-479).SOST中位数水平存在显着性别差异,在各种协变量(糖尿病,IR,年龄,体重,和种族)。值得注意的是,SOST水平因种族而异:阿拉伯人(677.4pg/mL,IQR-481.7),南亚人(914.6pg/mL,IQR-515),和东南亚人(695.2pg/mL,IQR-436.8).此外,SOST水平与性别呈显著正相关,年龄,腰围,收缩压和舒张压,空腹血糖,HbA1c,胰岛素,总胆固醇,甘油三酯,HDL,LDL,ALT,和AST(p值≥0.05)。南亚与会者,表现出最高的SOST水平,表现出最明显的联想,即使在调整了年龄之后,性别,BMI,和糖尿病状态(p值≥0.05)。观察到的SOST与各种临床参数的相关性表明其在糖尿病环境中的重要作用,与其他种族相比,南亚人口尤其明显。
Obesity and Type 2 Diabetes Mellitus (T2DM) are intricate metabolic disorders with a multifactorial etiology, often leading to a spectrum of complications. Recent research has highlighted the impact of these conditions on bone health, with a particular focus on the role of sclerostin (SOST), a protein molecule integral to bone metabolism. Elevated circulating levels of SOST have been observed in patients with T2DM compared to healthy individuals. This study aims to examine the circulating levels of
SOST in a multiethnic population living in Kuwait and to elucidate the relationship between
SOST levels, obesity, T2DM, and ethnic background. The study is a cross-sectional analysis of a large cohort of 2083 individuals living in Kuwait. The plasma level of
SOST was measured using a bone panel multiplex assay. The study found a significant increase in
SOST levels in individuals with T2DM (1008.3 pg/mL, IQR-648) compared to non-diabetic individuals (710.6 pg/mL, IQR-479). There was a significant gender difference in median
SOST levels, with males exhibiting higher levels than females across various covariates (diabetes, IR, age, weight, and ethnicity). Notably, SOST levels varied significantly with ethnicity: Arabs (677.4 pg/mL, IQR-481.7), South Asians (914.6 pg/mL, IQR-515), and Southeast Asians (695.2 pg/mL, IQR-436.8). Furthermore, SOST levels showed a significant positive correlation with gender, age, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, HbA1c, insulin, total cholesterol, triglycerides, HDL, LDL, ALT, and AST (p-Value ≥0.05). South Asian participants, who exhibited the highest SOST levels, demonstrated the most pronounced associations, even after adjusting for age, gender, BMI, and diabetes status (p-Value ≥0.05). The observed correlations of SOST with various clinical parameters suggest its significant role in the diabetic milieu, particularly pronounced in the South Asian population compared to other ethnic groups.