背景:化脓性关节炎是一种危险的疾病,当微生物进入滑液时就会发生。它需要快速准确的管理;否则,它会损害病人的生命。目前,测试测量SF中的WBC和PMN,所以我们假设使用一个更容易和更快测量的代理。白细胞酯酶是由嗜中性粒细胞分泌的酶,可在SA患者的滑液中发现。在这项研究中,我们试图研究白细胞酯酶在诊断化脓性关节炎中的敏感性和特异性。
方法:我们从46名怀疑患有脓毒性关节炎的患者和58名健康个体中获取了滑液样本,并测量了WBC,ESR,CRP,PMN,葡萄糖,和2021年SF的蛋白质。我们还使用白细胞酯酶试纸测试来研究关节液中的LE水平一分钟。
结果:根据临床和临床标准,46例患者中有16例被诊断为SA.当(++)被认为是积极的,LE试纸对SA诊断的敏感性和特异性分别为93.7%(95%CI:81.8-100%)和60%(95%CI:42.4-77.5%,P=0.000),分别。当(+)和(++)都被认为是阳性时,分别为100%和43.3%(95%CI:25.6-61.0%P=0.000),分别。对照组中的所有患者均具有阴性培养物和LE测试读数(特异性=100%)。
结论:LE试纸测试在SA的初始诊断中可能是有价值的诊断工具,因为它是负担得起的,快,和可靠的。
BACKGROUND: Septic arthritis is a dangerous disease that occurs when microorganisms enter synovial fluid. It needs fast and accurate management; otherwise, it can harm the patient\'s life. Currently, the tests measure WBC and PMN in SF, so we hypothesized to use a proxy that is easier and faster to measure. Leukocyte esterase is an enzyme secreted by neutrophils that can be found in the synovial fluid of SA patients. In this study, we tried to investigate the sensitivity and specificity of leukocyte esterase in diagnosing septic arthritis.
METHODS: We obtained synovial fluid samples from forty-six patients suspected of having septic arthritis and fifty-eight healthy individuals and measured the WBCs, ESR, CRP, PMN, glucose, and protein of SF in 2021. We also used the leukocyte esterase dipstick test to investigate the level of LE in synovial fluid for one minute.
RESULTS: Based on clinical and paraclinical criteria, sixteen out of the forty-six patients were diagnosed with SA. When (++) was considered positive, the sensitivity and specificity of the LE dipstick test for the diagnosis of SA were 93.7% (95% CI: 81.8-100%) and 60% (95% CI: 42.4-77.5%, P = 0.000), respectively. When both (+) and (++) were considered positive, they were 100% and 43.3% (95% CI: 25.6-61.0% P = 0.000), respectively. All the patients in the control group had negative cultures and LE test readings (specificity = 100%).
CONCLUSIONS: The LE dipstick test can be a valuable diagnostic tool in the initial diagnosis of SA since it is affordable, fast, and reliable.