目的:良性前列腺增生(BPH)是一种常见的慢性疾病,影响老年人的泌尿系统健康和生活质量。前列腺等离子电切术(PKRP)是治疗BPH的重要手术方法之一;老年人可能会出现麻醉并发症和术后疼痛.这项回顾性研究旨在评估术前口服加巴喷丁对接受PKRP治疗的老年BPH患者麻醉结果的影响,并为改善手术治疗效果提供详细的临床证据。
方法:对2021年3月至2023年3月在天津医院接受PKRP治疗的178例老年BPH患者的病历资料进行回顾性分析。排除18例未符合纳入标准的患者后,160名患者最终被纳入研究。根据术前使用加巴喷丁,将患者分为观察组(n=75,接受加巴喷丁)和对照组(n=85,未接受加巴喷丁)。基线数据,视觉模拟量表(VAS)评分,术后Ramsay镇静量表(RSS)评分,收集不良反应发生率。
结果:两组在年龄方面没有显着差异,身体质量指数,前列腺体积,手术持续时间,国际前列腺症状评分(IPSS)美国麻醉医师协会(ASA)分类,高血压和糖尿病病史,术后36小时和48小时的VAS评分,术后2小时RSS评分,4小时,8小时,12小时,24小时,36小时,和48小时(p>0.05)。与对照组相比,观察组术后2小时VAS评分明显降低,4小时,8小时,12小时,和24小时(p<0.001),术后24h内不良反应发生率明显降低(p<0.05)。
结论:术前给予加巴喷丁PKRP可减轻老年BPH患者的疼痛程度和不良反应发生率,提高麻醉效果。有利于术后恢复。
OBJECTIVE: Benign prostatic hyperplasia (BPH) is a common chronic disease affecting the health of the urinary system and the quality of life in older adults. Plasmakinetic resection of the prostate (PKRP) is one of the important surgical procedures for treating BPH; However, older adults may experience anesthesia complications and postoperative pain. This retrospective study aimed to assess the effects of preoperative oral gabapentin on anesthesia outcomes in older adults with BPH undergoing PKRP and to provide detailed clinical evidence for improving the impact of surgical treatment.
METHODS: The medical records of 178 older adults with BPH who underwent PKRP in Tianjin Hospital from March 2021 to March 2023 were retrospectively analyzed. After excluding 18 patients who did not meet the inclusion criteria, 160 patients were finally included in the study. According to preoperative use of gabapentin, patients were divided into the observation group (n = 75, received gabapentin) and the control group (n = 85, did not receive gabapentin). The baseline data, visual analog scale (VAS) scores, postoperative Ramsay Sedation Scale (RSS) scores, and incidence of adverse reactions were collected.
RESULTS: There were no significant differences observed between the two groups in terms of age, body mass index, prostate volume, surgery duration, International Prostate Symptom Score (IPSS), American Society of Anesthesiologists (ASA) classification, history of hypertension and diabetes mellitus, VAS scores at postoperative 36 hours and 48 hours, and RSS scores at postoperative 2 hours, 4 hours, 8 hours, 12 hours, 24 hours, 36 hours, and 48 hours (p > 0.05). Compared to the control group, the observation group had significantly lower VAS scores at postoperative 2 hours, 4 hours, 8 hours, 12 hours, and 24 hours (p < 0.001), and the incidence of adverse reactions was significantly lower within 24 hours after surgery (p < 0.05).
CONCLUSIONS: Preoperative administration of gabapentin before PKRP could reduce pain severity and the incidence of adverse reactions and improve anesthetic effects in older adults with BPH, which is conducive to postoperative recovery.