目的:本研究旨在评价胆道镜联合双套管灌洗在包裹性坏死急性胰腺炎(AP)治疗中的应用及相关炎性指标分析。
方法:纳入30例AP伴包裹性坏死患者,采用胆道镜和双套管灌洗治疗。血清白细胞(WBC),降钙素原(PCT),C反应蛋白(CRP),白细胞介素6(IL-6),IL-8,肿瘤坏死因子α(TNF-α),术前、术后检测相关炎症指标。
结果:所有接受手术的参与者恢复良好,无严重并发症,无死亡病例。血清白细胞,PCT,术后患者CRP较手术前下降,WBC和CRP差异有统计学意义(P<0.05);PCT差异无统计学意义(P>0.05)。术后,IL-6、IL-8、TNF-α水平高于术前,差异均有统计学意义(P<0.05)。
结论:本文提出的手术方法有效地控制和减轻了患者的感染,也没有增加感染的风险,因此可以认为是一种安全有效的手术方法。
OBJECTIVE: This study aimed to evaluate the application of choledochoscopy combined with double-cannula lavage in the treatment of acute pancreatitis (AP) with encapsulated necrosis and analyzed related inflammatory indexes.
METHODS: Thirty patients with AP with encapsulated necrosis were enrolled and treated with choledochoscopy and double-cannula lavage. Serum white blood cell (WBC), procalcitonin (PCT), C-reactive protein (CRP), interleukin 6 (IL-6), IL-8, tumor necrosis factor alpha (TNF-α), and related inflammatory indexes were detected before and after surgery.
RESULTS: All of the participants who underwent the surgery recovered well and were discharged without serious complications; no deaths occurred. The serum WBC, PCT, and CRP of patients after surgery decreased compared with before the procedure, and the differences in WBC and CRP were statistically significant (P < 0.05); the difference in PCT was not statistically significant (P > 0.05). Postoperatively, IL-6, IL-8, and TNF-α levels were higher than before surgery, and the differences were statistically significant (P < 0.05).
CONCLUSIONS: The surgical method presented herein effectively controlled and alleviated the infection of patients; it also did not increase the risk of infection and can thus be considered a safe and effective surgical method.