microRNAs(miRNAs)是一组小的非编码RNA,在控制生命过程中起着重要作用。包括细胞周期控制,凋亡,新陈代谢,发展和分化,导致各种疾病,如神经系统疾病,代谢紊乱,和癌症。化疗被认为是癌症患者的黄金治疗方法。然而,化疗是癌症治疗的主要挑战之一。多柔比星(DOX)是一种抗癌药物,可干扰癌细胞的生长和扩散。DOX用于治疗各种类型的癌症,包括乳房,神经组织,膀胱,胃,子房,甲状腺,肺,骨头,肌肉,关节和软组织癌。最近,miRNA已被鉴定为负责启动化学抗性的机制的特定基因的主要调节因子。miRNAs经由过程调控细胞凋亡对化疗耐药具有调控感化。此外,通过研究证实了miRNAp53基因作为关键肿瘤抑制因子的作用。miRNAs可以影响主要的生物学通路包括PI3K通路。这篇综述旨在介绍目前对miRNAs在细胞凋亡中的作用和机制的认识。p53和PTEN/PI3K/Akt信号通路与DOX抵抗有关。
MicroRNAs (miRNAs) are a group of small non-coding RNAs and play an important role in controlling vital biological processes, including cell cycle control, apoptosis, metabolism, and development and differentiation, which lead to various diseases such as neurological, metabolic disorders, and cancer. Chemotherapy consider as gold treatment approaches for cancer patients. However, chemotherapeutic is one of the main challenges in cancer management. Doxorubicin (DOX) is an anti-cancer drug that interferes with the growth and spread of cancer cells. DOX is used to treat various types of cancer, including breast, nervous tissue, bladder, stomach, ovary, thyroid, lung, bone, muscle, joint and soft tissue cancers. Also recently, miRNAs have been identified as master regulators of specific genes responsible for the mechanisms that initiate chemical resistance. miRNAs have a regulatory effect on chemotherapy resistance through the regulation of apoptosis process. Also, the effect of miRNAs p53 gene as a key tumor suppressor was confirmed via studies. miRNAs can affect main biological pathways include PI3K pathway. This review aimed to present the current understanding of the mechanisms and effects of miRNAs on apoptosis, p53 and PTEN/PI3K/Akt signaling pathway related to DOX resistance.