阿尔茨海默病代表了整个非洲的重大和不断升级的公共卫生威胁。阿尔茨海默病导致严重的认知障碍和记忆丧失,给受影响的个人及其家人带来沉重负担,朋友,和照顾者。它影响了非洲的267万人,大多数人生活在撒哈拉以南非洲。根据世界卫生组织的估计,到2050年,这种疾病的患病率预计将急剧上升到全球约1.5亿人。
■本文提供了非洲阿尔茨海默病的综合概况,跨越已知的遗传和可改变的风险,讨论了诊断和治疗中存在的挑战,到2050年,对患病率和残疾调整后的生命年负担的预测,以及重新平衡等式所需的优先政策对策。
■本文研究了现有文献,以总结当前关于风险因素的知识,诊断,治疗,以及非洲阿尔茨海默病的负担。收集流行病学评估,临床指南,和有关非洲老年痴呆症的评论。
■数据揭示了有关非洲阿尔茨海默病诊断和护理的现实。诊断基础设施缺陷,资源限制,知识差距是反复出现的障碍。正电子发射断层扫描,脑脊液化验,发达国家常见的其他主要检测方式显示出有限的可用性。
■解决非洲的阿尔茨海默病危机需要多管齐下的策略来提高诊断能力,治疗可用性,专业培训,公众意识,和协调的政策制定。优先考虑生物标志物和成像以确认早期神经变性是基础,除了扩大毒品准入。
UNASSIGNED: Alzheimer\'s disease represents a substantial and escalating public health threat across Africa. Alzheimer\'s disease leads to substantial cognitive impairment and memory loss, placing a heavy burden on the affected individuals and their families, friends, and caregivers. It affects 2.67 million people in Africa, the majority of whom live in sub-Saharan Africa. The prevalence of this disease is expected to rise drastically to approximately 150 million individuals worldwide by 2050, as estimated by the WHO.
UNASSIGNED: This paper offers an integrative profile of Alzheimer\'s disease in Africa, spanning known genetic and modifiable risks, discusses the existing challenges in diagnosis and treatment, projections on prevalence and disability-adjusted life year burden through 2050, and priority policy responses needed to rebalance the equation.
UNASSIGNED: This paper examines available literature to summarize current knowledge on risk factors, diagnosis, treatments, and burden of Alzheimer\'s disease in Africa. Gather epidemiological assessments, clinical guidelines, and commentary related to Alzheimer\'s disease in Africa.
UNASSIGNED: The data reveals concerning realities regarding Alzheimer\'s disease diagnosis and care in Africa. Diagnostic infrastructure shortcomings, resource limitations, and knowledge gaps emerge as recurring barriers. Positron emission tomography scans, cerebrospinal fluid assays, and other mainstay detection modalities common in developed countries show restricted availability.
UNASSIGNED: Addressing Africa\'s Alzheimer\'s disease crisis demands a multipronged strategy to uplift diagnostic capacities, treatment availability, specialist training, public awareness, and coordinated policymaking. Prioritizing biomarkers and imaging to confirm early neurodegeneration is foundational, alongside drug access expansion.