■肌筋膜触发点(MTrP)是肌筋膜疼痛综合征(MPS)的主要原因,MPS患者也有交感神经异常的症状。因此,本研究旨在探讨MTrPs与交感神经之间的潜在关系。
■将24只7周龄雄性大鼠随机分为4组(每组6只)。I组和II组保持正常状态(n=12),第III组和第IV组接受MTrP建模(n=12)。在成功的MTrP建模之后,观察了MTrPs组(III和IV)和非MTrPs组(I和II)之间交感神经结局的差异.然后将交感神经阻滞应用于III组和I组(n=12)。在交感神经阻滞之前和之后,收集了MTrP自发放电期间的峰值反转自发电位(PISP)和H反射诱发的肌电图数据。
■收缩压,舒张压,平均动脉压,MTrPs组心率明显高于非MTrPs组(P<0.05)。与I组相比,第三组PISP的潜在波幅较低,较短的持续时间和振幅与持续时间之比,和较低的H潜伏期和潜伏期差H-M(P<0.05)。与IV组相比,第三组PISP的潜在波幅较低,持续时间,振幅与持续时间比,M波延迟,H最大波振幅,最大波幅比H/M(P<0.05)。MTrPs组交感神经阻滞前后的变化是显著的,和振幅,持续时间,阻断后PISP电位的振幅与持续时间比降低(P<0.05)。
■MTrP和交感神经相互作用,形成特定的关系。MTrPs使交感神经敏感,交感神经异常会影响局部肌肉肌电过度活动,导致MTRP。这一发现对于交感神经障碍的临床管理具有指导意义。
UNASSIGNED: Myofascial trigger points (MTrPs) are the main cause of myofascial pain syndrome (MPS), and patients with MPS also have symptoms of sympathetic abnormalities. Consequently, this study aimed to investigate the potential relationship between MTrPs and sympathetic nerves.
UNASSIGNED: Twenty-four seven-week-old male rats were randomly divided into four groups (six rats every group). Groups I and II were kept in normal condition (n=12), and groups III and IV underwent MTrPs modelling (n=12). After successful MTrPs modelling, differences in sympathetic outcomes between the MTrPs groups (III and IV) and non-MTrPs groups (I and II) were observed. Sympathetic blockade was then applied to groups III and I (n=12). Data were collected on peak inversion spontaneous potentials (PISPs) and the H-reflex-evoked electromyography during spontaneous discharge at the MTrPs before and after sympathetic blockade.
UNASSIGNED: Systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate were significantly higher in the MTrPs group than in the non-MTrPs group (P<0.05). Compared with group I, group III had the PISPs potential lower wave amplitude, shorter duration and amplitude-to-duration ratio, and lower H latency and latency difference H-M (P<0.05). Compared with group IV, group III had the PISPs potential lower wave amplitude, duration, amplitude-to-duration ratio, M-wave latency, H maximum wave amplitude, and maximal wave amplitude ratio H/M (P<0.05). The changes before and after sympathetic blockade in the MTrPs group were significant, and the amplitude, duration, and amplitude-to-duration ratio of the PISPs potentials were lower after the blockade (P<0.05).
UNASSIGNED: MTrPs and sympathetic nerves interact with each other forming a specific relationship. MTrPs sensitize sympathetic nerves, and sympathetic nerve abnormalities affect local muscle myoelectric hyperactivity, leading to MTrPs. This finding is instructive for the clinical management of sympathetic disorders.