■当胎儿未能达到其生长潜力时,就会发生胎儿生长受限(FGR)。这项观察性研究评估了FGR孕妇血清中包含细胞迁移蛋白(CEMIP)和醛固酮合酶(CYP11B2)的表达和意义。
■40名单身FGR孕妇,以及40名正常单身孕妇,已注册。孕早期血清中CEMIP和CYP11B2的表达检测。评价各参数之间的相关性。确定了FGR的预测变量。分析CEMIP和CYP11B2对FGR的诊断价值。
■FGR孕妇血清中CEMIP和CYP11B2mRNA表达降低(均P<0.001)。血清CEMIP(95CI:0.802-0.921,P<0.001)和CYP11B2(95CI:0.795-0.907,P<0.001)mRNA表达及可溶性fms样酪氨酸激酶-1(sFLT1)/胎盘生长因子(PlGF)比值(95CI:0.866-0.974,P<0.001)是FGR的独立预测因子,血清中CEMIP(r=-0.578,P=0.001)和CYP11B2(r=-0.602,P<0.001)mRNA表达与sFLT1/PlGF比值呈负相关。血清CEMIP(AUC=0.741)和CYP11B2(AUC=0.764)mRNA表达对FGR有较好的诊断价值。
■CEMIP和CYP11B2在FGR孕妇血清中的表达降低,可能成为FGR新的诊断标志物。
胎儿生长受限是指胎儿由于各种因素而无法在子宫中达到其生长潜力。本研究旨在探讨胎儿生长受限孕妇血清中包含细胞迁移蛋白和醛固酮合成酶的表达及意义。在我们的研究中,我们发现胎儿生长受限孕妇血清中细胞迁移蛋白和醛固酮合酶的表达降低。细胞迁移-包括蛋白和醛固酮合酶的表达与可溶性fms样酪氨酸激酶-1/胎盘生长因子的比值呈负相关。此外,该研究还发现,血清中的细胞迁移蛋白和醛固酮合酶的表达对胎儿生长受限具有良好的诊断价值。
UNASSIGNED: Foetal growth restriction (FGR) occurs when a foetus fails to reach its growth potential. This observational study assessed the expression and significance of cell migration-including protein (CEMIP) and aldosterone synthase (CYP11B2) in the serum of pregnant women with FGR.
UNASSIGNED: 40 singleton FGR-suffered pregnant women, as well as 40 normal singleton pregnant women, were enrolled. The expression of CEMIP and CYP11B2 in serum was detected in early pregnancy. The correlations between parameters were evaluated. The predictive variables for FGR were determined. The diagnostic value of CEMIP and CYP11B2 for FGR was analysed.
UNASSIGNED: CEMIP and CYP11B2 mRNA expression in the serum of pregnant women with FGR decreased (both P < 0.001). CEMIP (95%CI: 0.802-0.921, P < 0.001) and CYP11B2 (95%CI: 0.795-0.907, P < 0.001) mRNA expression in serum and soluble fms like tyrosine kinase-1 (sFLT1)/placental growth factor (PlGF) ratio (95%CI: 0.866-0.974, P < 0.001) were independent predictors of FGR, and CEMIP (r = -0.578, P = 0.001) and CYP11B2 (r = -0.602, P < 0.001) mRNA expression in serum were negatively correlated with sFLT1/PlGF ratio. CEMIP (AUC = 0.741) and CYP11B2 (AUC = 0.764) mRNA expression in serum had good diagnostic value for FGR.
UNASSIGNED: The expression of CEMIP and CYP11B2 is reduced in the serum of pregnant women with FGR and may become new diagnostic markers for FGR.
Foetal growth restriction is the inability of the foetus to reach its growth potential in the uterus due to various factors. This study aimed to investigate the expression and significance of cell migration-including protein and aldosterone synthase in serum of pregnant women with foetal growth restriction. In our study, we found that the expression of cell migration-including protein and aldosterone synthase in serum of pregnant women with foetal growth restriction were decreased. Cell migration-including protein and aldosterone synthase expression was negatively correlated with soluble fms like tyrosine kinase-1/placental growth factor ratio. In addition, the study also found that cell migration-including protein and aldosterone synthase expression in serum had good diagnostic value for foetal growth restriction.