背景和目的:这项研究的目的是评估抗癫痫左乙拉西坦治疗是否会导致癫痫儿童的脑容量变化。为此,我们比较了基底神经节(尾状核,壳核,globus,臀部-足尖,和丘脑)在使用左乙拉西坦的小儿癫痫患者治疗前后(18-24个月)进行磁共振成像(MRI)。材料和方法:这项回顾性研究涉及在01.08.2019和01.11.2023之间到Balikesir大学医学院儿科神经病学诊所就诊并被诊断为癫痫的患者的体积比较,在放射科治疗前和治疗后18-24个月接受头颅MRI检查。人口统计学和临床特征(年龄,性别,癫痫家族史,癫痫的类型,和脑电图特征(正常,异常,记录研究中包括的患者的癫痫样)。结果:治疗前和治疗后18-24个月的头颅MRI基底节区体积的比较显示,左尾状核存在显着差异,右壳核,左壳核,左苍白球,右丘脑,左丘脑,和右侧海马区。结论:总之,在癫痫患者的头颅成像中会遇到不同的发现,根据癫痫发作的频率,活动,以及使用的抗癫痫药物的类型。这项研究比较了使用左乙拉西坦的小儿癫痫患者治疗前和治疗后18-24个月的颅骨MRI上的基底节体积。在基底神经节(尾状核,壳核,苍白球,海马体,和丘脑)对使用左乙拉西坦的小儿癫痫患者的MRI。
Background and Objectives: This study was performed for the purpose of assessing whether antiepileptic levetiracetam treatment produces a change in brain volumes in children with epilepsy. To that end, we compared the volumes of the basal ganglia (caudate nucleus, putamen, globus, hip-pocampus, and thalamus) at magnetic resonance imaging (MRI) before and after treatment (months 18-24) in pediatric epilepsy patients using levetiracetam. Materials and Methods: This retrospective study involved a volumetric comparison of patients presenting to the Balikesir University Medical Faculty pediatric neurology clinic between 01.08.2019 and 01.11.2023 and diagnosed with epilepsy, and who underwent cranial MRI before and 18-24 months after treatment at the radiology department. The demographic and clinical characteristics (age, sex, family history of epilepsy, type of epilepsy, and EEG features (normal, abnormal, epileptiform)) of the patients included in the study were recorded. Results: The comparison of basal ganglia volumes at cranial MRI before and at months 18-24 of treatment revealed significant differences in the left caudate nucleus, right putamen, left putamen, left globus pallidus, right thalamus, left thalamus, and right hippocampal regions. Conclusions: In conclusion, differing findings are encountered at cranial imaging in patients with epilepsy, depending on the seizure frequency, activity, and the type of antiepileptic drugs used. This study compared basal ganglia volumes on cranial MRIs taken before and 18-24 months after treatment in pediatric epilepsy patients using levetiracetam. A significant increase was observed in the volumes of basal ganglia (caudate nucleus, putamen, globus pallidus, hippocampus, and thalamus) on the MRIs of pediatric epilepsy patients using levetiracetam.