目的:运动员通常暴露于运动引起的脱水。然而,在这种情况下检测脱水的最佳方法尚不清楚。本研究旨在分析脱水前后生物标志物的测量,包括唾液渗透压(SOsm),尿渗透压(UOsm),尿液比重(USG),尿液颜色(Ucolor),血清渗透压(SeOsm),血清精氨酸加压素(AVP),血清钠(Na+),和水分不足的运动员的口渴感,使用体重损失(BML)作为参考方法。
方法:在本临床试验(NCT05380089)中,有规律的低饮水量(<35mL/kg/日)的38名运动员(17名女性)接受了运动诱导的脱水,热指数为29.8±3.1°C,跑步强度为个性化(第一通气阈值的80-90%).
结果:ROC曲线分析显示SOsm具有显著的辨别能力,在1.5%BML时AUC值为0.76,在1.75%BML时为0.75,在2%BML时为0.87,而Na+和SeOsm在2%BML时显示出0.87和0.91的最高AUC,分别。SOsm在BML的1.5%时表现出高灵敏度,而SeOsm和Na+在2%的BML时表现出高灵敏度。
结论:本研究强调SOsm是不同水平BML中水合状态的潜在指标。此外,Na+和SeOsm在BML的1.75%和2%时作为准确的脱水预测因子出现。值得注意的是,尿液指标和口渴感检测水合作用的准确性可能有限。
OBJECTIVE: Athletes are commonly exposed to exercise-induced dehydration. However, the best method to detect dehydration under this circumstance is not clear. This study aimed to analyze pre- and post-dehydration measurements of biomarkers, including saliva osmolality (SOsm), urine osmolality (UOsm), urine-specific gravity (USG), urine color (Ucolor), serum osmolality (SeOsm), serum arginine vasopressin (AVP), serum sodium (Na+), and thirst sensation in underhydrated athletes, using the body mass loss (BML) as the reference method.
METHODS: In this clinical trial (NCT05380089), a total of 38 athletes (17 females) with a regular low water intake (<35 mL/kg/day) were submitted to exercise-induced dehydration with a heat index of 29.8 ± 3.1 °C and an individualized running intensity (80-90% of first ventilatory threshold).
RESULTS: ROC curve analysis revealed significant discriminative abilities of SOsm, with AUC values of 0.76 at 1.5% BML, 0.75 at 1.75% BML, and 0.87 at 2% BML, while Na+ and SeOsm showed the highest AUC of 0.87 and 0.91 at 2% BML, respectively. SOsm showed high sensitivity at 1.5% of BML, while SeOsm and Na+ demonstrated high sensitivity at 2% of BML.
CONCLUSIONS: This study highlights SOsm as a potential indicator of hydration status across different levels of BML. Additionally, Na+ and SeOsm emerged as accurate dehydration predictors at 1.75% and 2% of BML. Notably, the accuracy of urinary indices and thirst sensation for detecting hydration may be limited.