{Reference Type}: Journal Article
{Title}: Removal of catheter distortion in multiple indicator dilution studies: a deconvolution-based method and case studies on glucose blood-tissue exchange.
{Author}: Sparacino G;Vicini P;Bonadonna R;Marraccini P;Lehtovirta M;Ferrannini E;Cobelli C;
{Journal}: Med Biol Eng Comput
{Volume}: 35
{Issue}: 4
{Year}: Jul 1997
{Factor}: 3.079
{DOI}: 10.1007/BF02534087
{Abstract}: The study of blood-tissue exchange by the multiple indicator dilution technique often needs frequent sampling in the blood of the indicator dilution curves (IDC). Usually, this requires the use of a catheter supported by a pump. This causes a distortion in the IDC, which must be removed for proper interpretation of the data. A deconvolution-based methodology to remove IDC distortion is presented. First, the catheter impulse response is modelled by means of data obtained from a suitable experiment. Then the reconstruction of the blood IDC is tackled by a new nonparametric deconvolution algorithm, which provides (quasi) time-continuous signals and exploits statistically based criteria for the choice of the regularisation parameter. The methodology is applied to the removal of catheter distortion in studies of glucose blood-tissue exchange in the human forearm and myocardium.