{Reference Type}: Journal Article
{Title}: Fabrication of injectable alginate hydrogels with sustained release of 4-octyl itaconate for articular anti-inflammatory.
{Author}: Bao R;Mao Y;Zhang Y;Chai J;Zhang Y;Luo C;Zhang K;Jiang G;He X;
{Journal}: Biomed Mater Eng
{Volume}: 35
{Issue}: 5
{Year}: 2024 Jul 26
{Factor}: 1.234
{DOI}: 10.3233/BME-240103
{Abstract}: <B>UNASSIGNED: </B>Osteoarthritis (OA) is a chronic and degenerative joint disease that remains a great challenge in treatment due to the lack of effective therapies. 4-octyl itaconate (4-OI) is a novel and potent modulator of inflammation for the treatment of inflammatory disease. However, the clinical usage of 4-OI is limited due to its poor solubility and low bioavailability. As a promising drug delivery strategy, injectable hydrogels offers an effective approach to address these limitations of 4-OI.<BR><B>UNASSIGNED: </B>The aim of the study was to verify that the composite 4-OI/SA hydrogels could achieve a controlled release of 4-OI and reduce damage to articular cartilage in the group of osteoarthritic rats treated with the system.<BR><B>UNASSIGNED: </B>In this study, an injectable composite hydrogel containing sodium alginate (SA) and 4-octyl itaconate (4-OI) has been developed for continuous intra-articular administration in the treatment of OA.<BR><B>UNASSIGNED: </B>After intra-articular injection in arthritic rats, the as-prepared 4-OI/SA hydrogel containing of 62.5 μM 4-OI effectively significantly reduced the expression of TNF-α, IL-1β, IL-6 and MMP3 in the ankle fluid. Most importantly, the as-prepared 4-OI/SA hydrogel system restored the morphological parameters of the ankle joints close to normal.<BR><B>UNASSIGNED: </B>4-OI/SA hydrogel shows a good anti-inflammatory activity and reverse cartilage disruption, which provide a new strategy for the clinical treatment of OA.